# Single Cell Analysis Core (Core C)

> **NIH NIH U19** · EMORY UNIVERSITY · 2024 · $371,349

## Abstract

PROJECT SUMMARY/ABSTRACT - CORE C: Single-Cell Analysis Core
HR arises from cell-to-cell variation of genotypic and metabolic processes. The goal of the Single-Cell Analysis
Core (Core C) is to provide experimentally-validated and yet difficult-to-perform single-cell-level analyses to
evaluate the mechanisms and dynamics of HR. Core C will support the single-cell-level studies proposed in all
three Projects by providing a centralized platform for culturing bacterial cells under well-controlled antibiotic
environments, measuring relevant processes at single-cell resolution, and performing image analysis as well as
necessary statistical analysis. Specifically, Core C will i) provide microfluidic continuous culture platform, ii)
quantify the copy number variation of resistance genes, and iii) determine metabolic activities of single cells in
heteroresistant populations. Core C activities will be conducted by Dr. Minsu Kim's laboratory in the Department
of Physics at Emory University, which has extensive expertise in single-cell-level imaging and analysis of gene
expression, metabolism, and physiology in bacteria. Dr. Kim was one of the first scientists to apply a single-cell
approach to antibiotic research and is considered a leading expert in this area. Dr. Kim and his team will work
with the PI of individual projects collaboratively to ensure they can successfully complete their projects in a timely
manner.

## Key facts

- **NIH application ID:** 10799596
- **Project number:** 5U19AI158080-04
- **Recipient organization:** EMORY UNIVERSITY
- **Principal Investigator:** Minsu Kim
- **Activity code:** U19 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $371,349
- **Award type:** 5
- **Project period:** 2021-03-05 → 2026-02-28

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10799596

## Citation

> US National Institutes of Health, RePORTER application 10799596, Single Cell Analysis Core (Core C) (5U19AI158080-04). Retrieved via AI Analytics 2026-05-21 from https://api.ai-analytics.org/grant/nih/10799596. Licensed CC0.

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