# Mechanistic insights into LSD actions at 5-HT2A serotonin receptors

> **NIH NIH R37** · UNIV OF NORTH CAROLINA CHAPEL HILL · 2024 · $650,756

## Abstract

Psychedelic drugs continue to be used and abused by large numbers of individuals within the
 US and recently there has been a resurgence of interest in the actions of psychedelic drugs like
 lysergic acid diethylamide (LSD). It is currently unknown how LSD and related psychedelic drugs
 exert their actions at the molecular and atomic levels. In this MERIT extension we will elucidate the
 molecular mechanisms by which LSD and related drugs interact with multiple G protein coupled
 receptors. We will also determine the potential relevance of differences between human and rodent
 receptors for the actions of LSD and related drugs in vitro and in vivo. Finally we will examine the
 effects of LSD and related drugs on the gene transcriptional changes which occur specifically in
 neurons which express receptor essential for the actions of LSD. Taken together, these new findings
 will provide molecular and atomic details regading the actions of psychedelic drugs in vitro and in
vivo.

## Key facts

- **NIH application ID:** 10799673
- **Project number:** 5R37DA045657-07
- **Recipient organization:** UNIV OF NORTH CAROLINA CHAPEL HILL
- **Principal Investigator:** Bryan L. Roth
- **Activity code:** R37 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $650,756
- **Award type:** 5
- **Project period:** 2023-03-01 → 2028-02-29

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10799673

## Citation

> US National Institutes of Health, RePORTER application 10799673, Mechanistic insights into LSD actions at 5-HT2A serotonin receptors (5R37DA045657-07). Retrieved via AI Analytics 2026-06-12 from https://api.ai-analytics.org/grant/nih/10799673. Licensed CC0.

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