# HIV and Substance Use Cohort Coordinating Center for Emerging and High Impact Scientific Cross Cohort Studies: HIV SUCCESS

> **NIH NIH U24** · UNIVERSITY OF WASHINGTON · 2024 · $838,133

## Abstract

The purpose of the HIV and Substance Use Cohort Coordinating Center for Emerging and High Impact
Scientific Cross Cohort Studies: HIV SUCCESS is to support National Institute on Drug Abuse funded cohorts
as they implement research strategies to better understand and address substance use and its consequences
among people with HIV (PWH). Substance use prevalence among PWH is high, and substance use patterns,
including increasing concurrent methamphetamine/opioid use as part of the 4th wave of the opioid epidemic,
continue to evolve. Substantial challenges remain to improve understanding and implementation of
interventions to address substance use and its impacts among PWH. Addressing these challenges is the
overarching purpose of the cohorts and requires a coordinating center (CC) experienced in data integration
and harmonization, health informatics, multi-site coordination, clinical care and intervention experience, and
HIV and substance use research to support the cohorts and comprehensively integrate cross-cohort data. The
resulting resource of comprehensively integrated data will give researchers the potential to address important
scientific and public health questions that would otherwise not be possible in individual cohorts. We will work
with cohorts to allow complex, careful and complete analyses of outcomes and results across diverse
populations using harmonized data. We will bring in data from other cohorts and studies as needed to ensure
that adequate clinical, biomarker, and/or genetic data are available to address key questions. Careful data
harmonization where appropriate will improve the statistical power to identify areas or sub-groups for research
focus and to understand what interventions are proving successful in the broader context of the whole
population of PWH (as opposed to the target population of a single cohort). This team brings vast experience
with HIV cohort data; data linkage and harmonization; methods development; statistical support including
causal inference from longitudinal observational data; health informatics platform and tool infrastructure and
development including data repositories and tools for efficient and accurate electronically collected patient
reported outcomes and outcomes adjudication; providing overall coordination for large collaborations of
cohorts and studies; a strong background in clinical epidemiology of HIV and substance use; and expertise in
applying this information to clinical care and interventions. We also have a comprehensive mentoring approach
to develop a new generation of HIV and substance use researchers. We will support cohorts to enhance data
collection where appropriate, merge and harmonize data when feasible, and work together to address key
questions on HIV, substance use, and outcomes that cannot be addressed by individual cohorts. By providing
project management, mentorship, and support, as well as developing a robust data repository, and
accomplishing the integration and l...

## Key facts

- **NIH application ID:** 10800814
- **Project number:** 5U24DA058307-02
- **Recipient organization:** UNIVERSITY OF WASHINGTON
- **Principal Investigator:** GEETANJALI CHANDER
- **Activity code:** U24 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $838,133
- **Award type:** 5
- **Project period:** 2023-04-01 → 2028-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10800814

## Citation

> US National Institutes of Health, RePORTER application 10800814, HIV and Substance Use Cohort Coordinating Center for Emerging and High Impact Scientific Cross Cohort Studies: HIV SUCCESS (5U24DA058307-02). Retrieved via AI Analytics 2026-06-02 from https://api.ai-analytics.org/grant/nih/10800814. Licensed CC0.

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