# Core C-Research Computing, Bioinformatics, and Biostatistics

> **NIH NIH P20** · UNIVERSITY OF MISSISSIPPI MED CTR · 2024 · $326,695

## Abstract

Core C-Abstract
The Molecular Center of Health and Disease (MCHD) will facilitate research under a central theme of
molecular physiology to enhance the depth of education, mentorship, and training of researchers to apply omics
technology and computational biology across the health-disease continuum. Research aimed at understanding
genetic susceptibility and molecular mechanisms involved in disease onset has the potential to halt progression
and return an individual to a healthier state. As advances in technology have allowed for insight into genomic,
transcriptomic, proteomic, and metabolomic complexity, the need to develop computational biology approaches
to integrate and merge these omics datasets along with physiological data (in total systems biology) has become
critical. In total, computational approaches applied to molecular, cellular, and overall pathophysiology associated
with the health-disease continuum can provide important systems biology level information. The mission of the
MCHD will be achieved through synergistic interaction across multiple components including Core A
(administrative oversight, education and mentoring programs, and a pilot project program), two research cores,
and three major project investigators to address diverse questions of health and disease using molecule and
computational approaches. In particular, Core C- Research Computing, Bioinformatics, and Biostatistics
will provide researchers access to high-performance research computing infrastructure, custom bioinformatics
analysis pipelines and biostatistical support. Core C will leverage the comprehensive state-of-the-art omics data
collection pipeline and mechanistic gene-editing and biological approaches from Core B to provide major project
and pilot investigators unique insight into the health-disease continuum. Core C will build new computing
infrastructure at the University, provide vital bioinformatics and computational biology analysis, facilitate a novel
“Bioinformatics and Data Sciences Collaborative”, and leverage and expand current biostatistics services
available through the School of Population Health. The objective of Core C is: (1) provide education and training
opportunities for faculty, trainees, and students in research computing and computational biology approaches;
(2) establish an innovative research computing infrastructure required for analyses of large omics datasets via
standard and custom analyses pipelines to return biologically relevant analyses to MCHD investigators; (3)
provide MCHD investigators access to biostatistical expertise and services for optimal experimental design,
statistical analyses, and interpretation of findings; and (4) to seek continuous improvement in research computing
infrastructure, services, and enhance analytical capabilities through implementation of new approaches,
algorithms, and methodology to assist in the sustainability of the Core. In total, through close coordination with
Core B, this core will estab...

## Key facts

- **NIH application ID:** 10802288
- **Project number:** 5P20GM144041-02
- **Recipient organization:** UNIVERSITY OF MISSISSIPPI MED CTR
- **Principal Investigator:** Hao Mei
- **Activity code:** P20 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $326,695
- **Award type:** 5
- **Project period:** 2023-03-06 → 2028-02-29

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10802288

## Citation

> US National Institutes of Health, RePORTER application 10802288, Core C-Research Computing, Bioinformatics, and Biostatistics (5P20GM144041-02). Retrieved via AI Analytics 2026-06-01 from https://api.ai-analytics.org/grant/nih/10802288. Licensed CC0.

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