# BLRD Research Career Scientist Award Application

> **NIH VA IK6** · VA PUGET SOUND HEALTHCARE SYSTEM · 2024 · —

## Abstract

Abstract
The main focus of our scholarly work has been conducting laboratory-based research into
aging-relevant neurodegenerative diseases with a particular focus on neurodegenerative
diseases impacting Veterans’ health. We have established a group of interdisciplinary
researchers to identify genes and pathways involved in aging-related neurodegenerative
disease for the purpose of developing small-molecule neuroprotective agents for
neurodegenerative diseases impacting Veterans’ health. In particular our group
investigates the molecular targets for intervention against tau and TDP-43 neurotoxicity
in neurons. For this approach we employ a variety of model systems including transgenic
C. elegans, transgenic rodent, and human cellular models of protein aggregation. These
models are used to uncover genes playing a conserved role in neurotoxicity. We
anticipate that work in model systems may provide insight into mechanisms of
neurodegeneration in human disease. We can thus use these findings to formulate
hypotheses of neurotoxicity and develop neuroprotective strategies accordingly. Our
ultimate goal is to validate neuroprotective strategies using mammalian systems to de-
risk future development of therapeutic approaches for conditions impacting Veteran’s
health with a particular focus on Alzheimer’s disease and ALS (a service connected
condition).

## Key facts

- **NIH application ID:** 10806863
- **Project number:** 1IK6BX006467-01
- **Recipient organization:** VA PUGET SOUND HEALTHCARE SYSTEM
- **Principal Investigator:** Brian C. Kraemer
- **Activity code:** IK6 (R01, R21, SBIR, etc.)
- **Funding institute:** VA
- **Fiscal year:** 2024
- **Award amount:** —
- **Award type:** 1
- **Project period:** 2023-10-01 → 2028-09-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10806863

## Citation

> US National Institutes of Health, RePORTER application 10806863, BLRD Research Career Scientist Award Application (1IK6BX006467-01). Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/grant/nih/10806863. Licensed CC0.

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