# The importance of Lysyl Oxidase in Atherosclerosis

> **NIH NIH F32** · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · 2024 · $89,488

## Abstract

Abstract
This F32 fellowship award aims to facilitate the training and career transition of Dr. Filipe Fernandes Stoyell-
Conti, Ph.D., an outstanding minority candidate, in vascular biology and atherosclerosis. Specifically, the grant
offers to Dr. Fernandes Stoyell-Conti the possibility of improving his hands-on skills in the laboratory,
strengthening his critical thinking and advancing his knowledge in bioinformatics and vascular biology. He will
receive training while investigating the role of lysyl oxidase (LOX), a copper-dependent amine oxidase, in smooth
muscle cells (SMCs) biology and atherosclerosis. Dr. Fernandes Stoyell-Conti research hypothesis is that LOX
facilitates SMC cell migration, inflammation, and foam cell formation during atherogenesis. In three specific aims,
he will: 1) investigate whether inactivation of LOX in SMCs compromises in vivo phenotypic switch of SMC, 2)
demonstrate that expression of LOX in SMC increases atherosclerosis in hyperlipidemic mice, and 3) examine
the molecular mechanisms by which LOX changes gene expression in SMCs. He will combine state of the art
animal models, transcriptomics (RNA-seq) and molecular biology to demonstrate that LOX can “turn off/on” gene
transcription in SMCs to make them more atherogenic. Together, these studies will advance his knowledge about
LOX's role in atherosclerosis and facilitate his transition towards independence as principal investigator in the
field of vascular biology and cardiovascular disease.

## Key facts

- **NIH application ID:** 10806925
- **Project number:** 5F32HL158216-03
- **Recipient organization:** UNIVERSITY OF MIAMI SCHOOL OF MEDICINE
- **Principal Investigator:** Filipe Fernandes Stoyell-Conti
- **Activity code:** F32 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $89,488
- **Award type:** 5
- **Project period:** 2022-02-01 → 2025-01-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10806925

## Citation

> US National Institutes of Health, RePORTER application 10806925, The importance of Lysyl Oxidase in Atherosclerosis (5F32HL158216-03). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10806925. Licensed CC0.

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