# Autonomic and Vascular Mechanisms of Cardiovascular Risk in Women with Post-traumatic Stress Disorder (PTSD)

> **NIH NIH K01** · UNIVERSITY OF MINNESOTA · 2024 · $132,204

## Abstract

PROJECT SUMMARY
The ultimate objective of this K01 proposal is to enable Dr. Ida Fonkoue to become an independent research
investigator by 1) developing expertise in vascular, hormonal and sleep measures in humans; 2) acquiring
scientific growth through a rigorous training plan, within an outstanding scientific environment that has a long
tradition in translational vascular research; and 3) generating sufficient preliminary results to support an NIH
R01 application. The candidate’s long-term goal is to build an NIH-funded research program in clinical and
translational research in women’s health, studying derangements of vascular, neural and hormonal control,
that contribute to the high rates of hypertension and cardiovascular disease (CVD) in women living with chronic
stress exposure such as those with post-traumatic stress disorder (PTSD), generalized anxiety disorder or
panic disorder.
 Over 7 million U.S. adults have PTSD, a disorder associated with a greater risk for hypertension and
CVD. While healthy premenopausal women are relatively protected from CVD compared to men, a diagnosis
of PTSD increases CVD risk in women by up to 3-fold. Understanding the mechanisms underlying CVD risk in
women with PTSD is of paramount importance to develop intervention strategies aiming at protecting the future
health of this vulnerable population. Based on our preliminary data, the working hypothesis of this project is
that: PTSD inhibits nitric oxide bioavailability, resulting in decreased endothelial function, increased arterial
stiffness and increased sympathetic activation; and that these changes are exacerbated by low estradiol levels
and sleep disturbances. Aim 1 will identify alterations in SNS activity in premenopausal women with PTSD and
determine if these alterations are a function of low E2 levels and sleep disturbances. Aim 2 will Identify
alterations in vascular function in premenopausal women with PTSD and determine if these alterations are a
function of low E2 levels and sleep disturbances.
 Emory University, where the PI’s entire mentoring team is located, boasts an intellectually rich research
environment whose resources will be used to carry out the proposed research, including an NIH-funded
Georgia Clinical and Translational Science Alliance (GA CTSA). During this K01 award, the PI will devote 75%
effort to this project and career development-related activities as highlighted in her four years training and
research plans. She will complete a Master of Science in Clinical Research offered by the GA CTSA and
prepare future career development grant submission. This research project, combined with multidisciplinary
mentorship, didactic education, and practical experience, will provide Dr. Fonkoue with the training and skills to
become a successful independent investigator.

## Key facts

- **NIH application ID:** 10807067
- **Project number:** 5K01HL161027-03
- **Recipient organization:** UNIVERSITY OF MINNESOTA
- **Principal Investigator:** Ida Tchuisseu Fonkoue
- **Activity code:** K01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $132,204
- **Award type:** 5
- **Project period:** 2022-04-01 → 2026-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10807067

## Citation

> US National Institutes of Health, RePORTER application 10807067, Autonomic and Vascular Mechanisms of Cardiovascular Risk in Women with Post-traumatic Stress Disorder (PTSD) (5K01HL161027-03). Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/grant/nih/10807067. Licensed CC0.

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