PROJECT SUMMARY/ABSTRACT Individuals with bipolar disorder (BD) are impacted by high rates of cigarette smoking and low quit rates. As such, there is a need to intervene on tobacco use among individuals with BD though, to date, there remain few effective treatments for addressing tobacco use in this population. Delay discounting, or the tendency to devalue a reward with increasing time to reward receipt, is a mechanistic process that is common to both BD and tobacco use. Specifically, studies suggest that individuals with BD and tobacco use, respectively, prefer smaller, immediate, rewards over larger, delayed rewards. The goal of this proposal is to assess the feasibility and acceptability of a 6-session episodic future thinking intervention (“Future Self-BD”) for decreasing delay discounting among individuals with BD and comorbid tobacco use disorder. Future Self-BD involves the vivid mental simulation of positive future events that participants anticipate will be benefited by smoking cessation. The primary hypotheses of this study are that Future Self-BD will be highly acceptable and feasible. We also hypothesize that, as exploratory outcomes, Future Self-BD will be associated with reductions in delay discounting as well as increased likelihood of attempting any smoking cessation treatment, increased motivation to quit smoking, and increased self-efficacy for smoking abstinence, compared to a control intervention (Daily Check-Ins). All participants will also receive brief cognitive-behavioral based smoking cessation counseling. The proposed study will occur alongside core training activities to establish expertise in the development and adaptation of psychosocial interventions (especially for serious mental illness), clinical trials methodology for tobacco use disorder, and advanced statistical modeling. The training plan will be implemented under the expert guidance of Dr. Louisa Sylvia (Primary Mentor), Dr. A. Eden Evins (Co-Mentor), Dr. Dustin Rabideau (Advisor), Dr. Leonard Epstein (Consultant), and Dr. Warren Bickel (Consultant). This combined research and training program will enable the candidate to become an independent clinical research scientist specializing in the intersection between serious mental illness and comorbid substance use disorders. There is a need for adjunctive behavioral interventions that can address the burden of tobacco use in BD, and this intervention holds great promise as a potential pathway for decreasing the over-valuation of short-term rewards that is in turn linked to smoking behavior.