PROJECT SUMMARY/ABSTRACT This NCI K08 Mentored Career Development Award will prepare Dr. Daniel Richardson to become an independent R01-level investigator in patient-centered cancer care delivery for patients with acute myeloid leukemia (AML). AML treatment paradigms are changing for older patients. After almost 40 years without any new treatments, 10 new therapies have been approved since 2017. These approvals have introduced clinical equipoise into treatment decision-making for many older patients. Choosing the “best” treatment option often depends on what each patient values most: optimizing quality of life or prolonging survival. Clinicians and patients can engage in shared decision-making to clarify patient values and help patients arrive at informed preferences about therapy. Multiple stakeholders have called for the development of new tools to support patients and clinicians in this complicated process. Dr. Richardson plans to work under the guidance of his mentors to evaluate a novel values elicitation tool called “PRIME” (Preference Reporting to Improve Management and Experience). PRIME generates a personalized values report in real-time to inform shared decision-making based on best-worst scaling (BWS), a simple yet robust values clarification method. This proposal builds on Dr. Richardson’s previous research with his mentors to develop values elicitation surveys for AML patients. The objective of this proposal is to evaluate the feasibility of using PRIME to improve treatment decisions and optimize its implementation for a RCT to evaluate efficacy. The aims of this study are (1) to determine the feasibility of using PRIME to improve treatment decision-making and (2) to identify barriers and facilitators of implementing PRIME into clinical workflows to inform development of appropriate implementation strategies. Success in this project will advance innovative, rigorous methods to capture patient values that may have broad applicability across oncology. This project will also promote Dr. Richardson’s long- term research goal of improving the integration of patient values into treatment decision-making. Dr. Richardson is supported by a mentorship team with expertise in values elicitation (John Bridges, PhD), implementation science (Stephanie Wheeler, PhD), and cancer care delivery trials (Ethan Basch, MD, Antonia Bennett, PhD). As part of this K08 award, he will develop expertise in cancer care delivery trial design and execution, values elicitation methodology, and implementation science.