# Elucidating the mechanism behind oscillation between glycolysis and gluconeogenesis

> **NIH NIH R35** · UNIVERSITY OF CALIFORNIA LOS ANGELES · 2023 · $11,384

## Abstract

Project Summary
Metabolism is a dynamic network of biochemical reactions capable of adapting to changing environments. In
changing glucose availability, glycolysis and gluconeogenesis support systemic glucose homeostasis. In the
parent award, we investigate the regulation and coordination of glycolysis and gluconeogenesis in mammalian
cells under dynamic nutrient environments. The goal of this supplement application is to acquire funding to
support one talented and motivated undergraduate student researcher for 10 weeks in the summer of 2023. She
will measure the rates of glycolysis and gluconeogenesis in mammalian cells under dynamic nutrient
environments by employing biochemical assays and mass spectrometry. She will be mentored by the PI and
one PhD student who will train her to perform cell culture experiments, metabolic measurements, and analyze
results. She will join the Bruins-In-Genomics (BIG) Summer Program on UCLA campus to broaden her scientific
horizons and develop professional skills. She will share her research outcomes with the PI’s research group and
other researchers on campus by presenting her project at the 2023 BIG Research Symposium. These activities
will further the undergraduate student researcher’s passion for biomedical science and act as a steppingstone
for her to become a future STEM leader.

## Key facts

- **NIH application ID:** 10807519
- **Project number:** 3R35GM143127-03S1
- **Recipient organization:** UNIVERSITY OF CALIFORNIA LOS ANGELES
- **Principal Investigator:** Junyoung O. Park
- **Activity code:** R35 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2023
- **Award amount:** $11,384
- **Award type:** 3
- **Project period:** 2021-07-01 → 2026-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10807519

## Citation

> US National Institutes of Health, RePORTER application 10807519, Elucidating the mechanism behind oscillation between glycolysis and gluconeogenesis (3R35GM143127-03S1). Retrieved via AI Analytics 2026-05-27 from https://api.ai-analytics.org/grant/nih/10807519. Licensed CC0.

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