# Developing natural compound emodin as a therapy for alcoholic cardiomyopathy

> **NIH NIH UT1** · ACEPRE, LLC · 2024 · $461,518

## Abstract

Project Summary: Alcoholic Cardiomyopathy (ACM) is the most prevalent form of ethanol-induced heart
damage. Alcohol dose-dependently induces ACM, characterized by progressive reduction in myocardial
contractility and ventricular dilatation, culminating in heart failure. At the cellular level, chronic alcohol
consumption results in cardiomyocyte death, cardiac inflammation, and cardiac fibrosis. There are currently no
FDA-approved therapies for ACM. The long-term goal of this project is to advance emodin, a small molecule
natural compound with anti-inflammatory, anti-apoptotic, and anti-fibrotic activities, for ACM prevention or
treatment. We have generated a robust body of background data in the basic science and early discovery
phase that supports emodin as a novel therapy for ACM including: 1) TGFβ signaling is the primary underlying
mechanism responsible for alcohol-induced cardiac fibrosis, a key component of ACM pathogenesis, 2)
Emodin is an effective inhibitor of TGFβ canonical and non-canonical signaling in multiple cell types, 3) The
pharmacokinetics (PK) and excellent safety of emodin have been examined in murine models, and 4) At non-
toxic oral doses, emodin effectively ameliorates cardiac fibrosis and dysfunction associated with doxorubicin, a
pathology similar to ACM. Furthermore, our preliminary data illustrates that emodin attenuates alcohol-induced
loss of cardiomyocyte viability and activation of cardiac fibroblasts. We propose to further test the central
hypothesis that emodin can be developed as a safe and effective preventive and/or therapeutic agent for ACM.
In this Phase 1 STTR application, we propose to examine the PK, safety, and efficacy of emodin in chronic
alcohol consumption rodent models and perform a PK and toxicity study in pigs in the following three specific
aims. SA1. To test if alcohol consumption influences emodin metabolism and evaluate the safety and efficacy
of emodin in ameliorating ACM in mouse models. SA2. To examine the PK, safety, and efficacy of emodin in
reducing cardiac fibrosis and cardiac dysfunction in alcohol-fed rats in both prevention and treatment settings.
SA3.To perform a PK and safety study of emodin in pigs and find a safe dose range that may achieve effective
blood emodin concentrations. By the end of the funding period of this STTR Phase 1 application, we will
possibly move emodin towards the next phase of drug development: IND-enabling preclinical study. Milestones
for a Go/no-go decision include: 1) if emodin does not exaggerate alcohol-induced toxicities in mice and rats,
particularly liver toxicity; 2) if there is significant efficacy of emodin in ameliorating ACM in mice and rats; and
3) if an appropriate safe dose is identified in pigs that can be extrapolated to humans. If answers to the above
three questions are positive, the decision will be made to further the development process of emodin, and a
Phase II application will be submitted to perform an IND-enabling preclinical stud...

## Key facts

- **NIH application ID:** 10808869
- **Project number:** 5UT1AA030690-02
- **Recipient organization:** ACEPRE, LLC
- **Principal Investigator:** WAYNE E CARVER
- **Activity code:** UT1 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $461,518
- **Award type:** 5
- **Project period:** 2023-03-15 → 2026-02-28

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10808869

## Citation

> US National Institutes of Health, RePORTER application 10808869, Developing natural compound emodin as a therapy for alcoholic cardiomyopathy (5UT1AA030690-02). Retrieved via AI Analytics 2026-05-27 from https://api.ai-analytics.org/grant/nih/10808869. Licensed CC0.

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