Project Summary The Administrative Core (Core B) will provide administrative leadership and effective project management for this HIVRAD Program Project. Core B will oversee scientific progress relative to project aims and milestones and lead scientific efforts in conjunction with the Scientific Advisory Board. It will coordinate financial management, research program management, regulatory compliance, and reporting functions. In addition to coordinating these activities, the Administrative Core will be responsible for promoting and documenting all aspects of scientific, regulatory, and financial compliance at Caltech and the subcontracting institutions. Dr. Pamela J. Bjorkman will serve as the Core Leader, with staff located within her administrative office as well as those of Vielmetter, Hahn, Shaw, and Nussenzweig, thus comprising a highly experienced and integrated management team. The Administrative Core will 1) Organize and govern the HIVRAD Program Project and 2) Coordinate the interactions between the three Projects and with the broader scientific community. This includes arranging formal communications among investigators, preparing protocol submissions and annual renewals to the Institutional Animal Care and Use (IACUC) committees, coordinating material transfer agreements, preparing reports and manuscripts, monitoring budgets, planning annual meetings and monthly conference calls, maintaining the HIVRAD website, and generally overseeing the scientific and administrative needs of the Program Project. In addition, the Administrative Core staff will assist in the effective sharing of data by maintaining shared cloud-based notebooks and databases and ensure that the NIH Data Management and Sharing Plans are implemented.