Project Summary/Abstract - Molecular Genetics Core To understand complex biologic systems relevant to human disease, modern biomedical research relies on the development of model organisms that mimic human physiology and pathophysiology. Indeed, genetic models of human disease are crucial for hypothesis driven research and hypothesis testing in vivo. Having the capacity to generate modern molecular tools is critical to scientific progress. Hence, the primary objectives of the MGC are to provide expertise, consultation, training, and services enabling the development and use of state-of-the-art genetic tools in support of diabetes-focused research, its complications and related endocrine and metabolic disorders.