# BLRD Research Career Scientist Award Application

> **NIH VA IK6** · SOUTH TEXAS VETERANS HEALTH CARE SYSTEM · 2024 · —

## Abstract

The etiology of Parkinson's disease (PD) is largely unknown. Preclinical and epidemiological studies provide a
strong link between old age, prior exposure to pesticides and the increased risk of developing Parkinson's
disease. This is of particular relevance to the VA because military personnel are often exposed to environmental
toxins, including pesticides, during deployment. Moreover, the veteran population is older than the U.S.
population and thus at increased risk. Recent evidence supports a role for elevated biogenic aldehydes in PD.
The work proposed will not only help to elucidate the mechanisms underlying Parkinson's disease, but it will
determine whether agents that lower biogenic aldehydes may be neuroprotective in Parkinson's disease. The
test agent and potential alternatives are FDA-approved drugs for which there is abundant information on their
safety and efficacy. Therefore, if these preclinical studies show efficacy in models of PD, then they may be more
easily tested clinically.

## Key facts

- **NIH application ID:** 10813056
- **Project number:** 5IK6BX006289-02
- **Recipient organization:** SOUTH TEXAS VETERANS HEALTH CARE SYSTEM
- **Principal Investigator:** RANDY STRONG
- **Activity code:** IK6 (R01, R21, SBIR, etc.)
- **Funding institute:** VA
- **Fiscal year:** 2024
- **Award amount:** —
- **Award type:** 5
- **Project period:** 2023-04-01 → 2030-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10813056

## Citation

> US National Institutes of Health, RePORTER application 10813056, BLRD Research Career Scientist Award Application (5IK6BX006289-02). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10813056. Licensed CC0.

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