# Cancer Genomics Shared Resource

> **NIH NIH P30** · WAKE FOREST UNIVERSITY HEALTH SCIENCES · 2024 · $45,960

## Abstract

CANCER GENOMICS SHARED RESOURCE (CGSR): PROJECT SUMMARY
The overarching objective of the Cancer Genomics Shared Resource (CGSR)is to maximize the scientific impact
of basic, translational, and clinical cancer research at the Wake Forest Baptist Comprehensive Cancer Center
(WFBCCC). CGSR achieves this objective by providing rapid and cost-effective access to state-of-the-art next-
generation sequencing (NGS) technologies and services, while promoting interdisciplinary collaboration and
education in genomic sciences. CGSR services support a range of research proje cts chiefly directed at the
discovery and characterization of genomic, transcriptomic, and/or epigenetic alterations that: (1) underlie cancer
formation and progression; (2) predict clinical cancer behavior and treatment outcomes; (3) define inter- and
intra-tumoral molecular and clonal heterogeneity; and (4) impact tumor-immune and drug-response interactions.
CGSR prioritizes cancer-related funded research, creates an optimal environment for the rapidly developing
Cancer Center’s Precision Oncology Initiative, as set forth in its Strategic Plan, and partners with other shared
resources to promote integrated cross-shared resource service workflows for advanced genomic applications,
such as single-cell sequencingand spatial single-cell gene expression profiling. CGSR is co-led by Lance Miller,
MS, PhD and GregoryHawkins, PhD, who have established records in cancer genomics research and funding.
CGSR is operated by four full-time technicians with advanced genomics expertise. To expedite data processing
and analysis, a staff bioinformatician is shared between the CGSR and the Bioinformatics Shared Resource.
During the current funding cycle, CGSR has expanded from2.5 to 4.0 full-time technicians, grown its sequencing
services by more than 3-fold, established single-cell sequencing platforms, introduced automation of NGS library
preparation, upgraded NGS sequencing capacity, raised its user base from 39 to 57 WFBCCC members, and
coordinated multiple successful collaborations with other WFBCCC Shared Resources. Du ring the current
funding cycle (11/01/15–10/31/20), CGSR provided genomic services to 92 investigators, 57 (62%) of whom
were WFBCCC members. Notably, 70% of CGSR’s total service capacity (measured by total staff -hours) was
utilized by WFBCCC members. CGSR services directly supported 34 cancer-focused publications and
contributed to the successful award of 22 NCI grants (12 R01s, 5 R21s, 2 R37s, 1 R33, 1 U01, and 1 K22) and
cancer-focused grants from the Department of Defense (five), American Cancer Society (two), and other
foundations (five).

## Key facts

- **NIH application ID:** 10813813
- **Project number:** 5P30CA012197-49
- **Recipient organization:** WAKE FOREST UNIVERSITY HEALTH SCIENCES
- **Principal Investigator:** Boris Pasche
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $45,960
- **Award type:** 5
- **Project period:** 1997-02-01 → 2027-01-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10813813

## Citation

> US National Institutes of Health, RePORTER application 10813813, Cancer Genomics Shared Resource (5P30CA012197-49). Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/grant/nih/10813813. Licensed CC0.

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