# Tumor Tissue and Pathology Shared Resource

> **NIH NIH P30** · WAKE FOREST UNIVERSITY HEALTH SCIENCES · 2024 · $41,576

## Abstract

TUMOR TISSUE AND PATHOLOGY SHARED RESOURCE (TTPSR): PROJECT SUMMARY
The Tumor Tissue and Pathology Shared Resource (TTPSR) of Wake Forest Baptist Comprehensive Cancer
Center (WFBCCC) facilitates translational cancer research by: (1) collecting and supplying high quality, well-
characterized human and animal tissues (neoplastic and normal) and (2) providing various pathology services
to WFBCCC investigators. The TTPSR maintains a repository of patient-derived tumors and matched normal
tissues, accompanied by pertinent clinical information, in addition to tissues from other species. It facilitates
investigators’ access to available data on tumor and normal tissues, serum, plasma, and white blood cells via
the Translational Data Warehouse and Informatics for Integrating Biology and the Bedside (i2b2), as well as the
Shared Resources’ web-based biospecimen management tool, in a regulatory-compliant manner. TTPSR also
assists investigators with the customized collection of fresh human and animal t issue samples for prospective
translational research projects. TTPSR includes the Tumor Procurement Lab (TPL), the Human Pathology Lab
(HPL), the Comparative Pathology Lab (CPL), and the Organoid Processing Lab (OPL). HPL works closely with
TPL for quality control of samples and provides clinical pathology expertise to investigators. CPL provides unique
samples and pathology expertise for a variety of experimental animals ranging from rodents to non -human
primates. OPL is a newly added lab to TTPSR, which is a collaborative entity with the Wake Forest Organoid
Research Center. OPL focuses on the formation of 3D patient-specific tumor organoids and applying them
translationally, with the goal of informing personalized cancer treatments as well as research and development
of new therapies. All four laboratories comprising TTPSR have one centralized reception point for seamless
operations and they are equipped with state-of-the-art instrumentation overseen by trained staff. TTPSR
provides high quality tissue samples with a stringent quality control process by a certified pathologist.It maintains
a formalin-fixed, paraffin-embedded tissue bank dedicated for research use. In addition, TTPSR provides
investigators with both pre-made tissue microarrays (TMAs) of various tissue types, as well as custom-made
TMAs for specific research questions. TTPSR also provides automated tissue dissociation in collaboration with
the Cancer Genomics Shared Resource for single cell RNAseq, to help investigators answer inquiries into the
cell type makeup of the tumor microenvironment. New services include collection of pediatric cases, and
production of TMAs and organoids. The TTPSR leadership consists of Edward Levine, MD, Director, and his
highly qualified team: Gregory Kucera, PhD Faculty Manager, (TPL) and the leaders of the three TTPSR Labs,
Wencheng Li, MD, Faculty Manager (HPL), David Caudell, DVM, PhD, Faculty Manager (CPL), and
Konstantinos Votanopoulos, MD, PhD, Faculty M...

## Key facts

- **NIH application ID:** 10813824
- **Project number:** 5P30CA012197-49
- **Recipient organization:** WAKE FOREST UNIVERSITY HEALTH SCIENCES
- **Principal Investigator:** Boris Pasche
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $41,576
- **Award type:** 5
- **Project period:** 1997-02-01 → 2027-01-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10813824

## Citation

> US National Institutes of Health, RePORTER application 10813824, Tumor Tissue and Pathology Shared Resource (5P30CA012197-49). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10813824. Licensed CC0.

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