# 3D Multi-Functional Catheter-Based Imaging of Coronary Lesion Composition, Structure, and Hemodynamics in Intermediate Stenoses

> **NIH NIH R01** · GEORGIA INSTITUTE OF TECHNOLOGY · 2024 · $609,287

## Abstract

PROJECT SUMMARY / ABSTRACT
More than 1 million patients in the U.S. undergo cardiac catheterization each year, and more than 200k of these patients
have stable coronary artery disease. Approximately 10% of patients with stable disease will experience a major adverse
event within a given two year period. Current imaging approaches based on independent indicators have largely failed to
predict adverse events, thus there are currently no techniques capable of determining which patients are likely to
experience adverse events such as myocardial infarction (MI). The ability to make treatment decisions based on
comprehensive, simultaneous measurements of the complete coronary environment—including biomechanics and
hemodynamics—rather than independent indicators could improve outcomes and reduce costs in at-risk patients.
This project proposes to develop a very small, forward-viewing ultrasound catheter capable of simultaneously
interrogating the comprehensive 3D coronary environment in order to guide decisions in the cardiac catheterization lab.
Specifically, the CoSHIS catheter (Composition, Structure, and Hemodynamics in Intermediate Stenoses) will
simultaneously quantify the coronary environment (including plaque mechanics and blood flow) in real-time 3D, unlike
current imaging approaches that seek to identify independent indicators of plaque rupture. In order to enable this multi-
functional quantification to guide treatment decisions, technological development is needed to ensure accurate
performance in a very small form factor. By leveraging recent advances in ultrasound imaging technology including array
design, data reconstruction, high frame rate image formation, and internal flow catheters designed to minimize flow
disturbance, this project will develop the core technology on for 4D mapping of the coronary mechanical enviornment
This technology for imaging-guided intervention in the cardiac catheterization lab will unite expertise in ultrasound
imaging and technology development, imaging-based computational modeling, animal models of coronary artery disease,
and interventional cardiology, and will be developed according to the following three Aims:
1. Development of a forward-viewing system for 3D intravascular ultrasound (US) imaging of lesion morphology,
hemodynamics, and plaque composition.
2. Validation of novel ultrasound measurement technology with established techniques including computed tomography
(CT), computational fluid dynamics (CFD) based on angiography, and virtual histology intravascular ultrasound.
3. Evaluation of simultaneous US-based measurement in animal models of intermediate stenoses with validation using
established techniques.

## Key facts

- **NIH application ID:** 10814167
- **Project number:** 5R01EB031101-04
- **Recipient organization:** GEORGIA INSTITUTE OF TECHNOLOGY
- **Principal Investigator:** Brooks D Lindsey
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $609,287
- **Award type:** 5
- **Project period:** 2021-07-01 → 2026-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10814167

## Citation

> US National Institutes of Health, RePORTER application 10814167, 3D Multi-Functional Catheter-Based Imaging of Coronary Lesion Composition, Structure, and Hemodynamics in Intermediate Stenoses (5R01EB031101-04). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10814167. Licensed CC0.

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