# Histology, Biomechanics, and Human Tissue Core

> **NIH NIH P20** · UNIV OF ARKANSAS FOR MED SCIS · 2024 · $232,228

## Abstract

PROJECT SUMMARY/ABSTRACT – CORE C
 The goal of the Histology, Biomechanics, and Human Tissue Core (Core C) is to provide state-of-the-art
services for the characterization of tissue and cellular changes that underlie the pathological mechanisms of
skeletal diseases in both mice and humans. The core will provide 3 services: 1) high quality and reliable hard-
tissue histology services that will help investigators identify the cellular basis of musculoskeletal changes and
formulate new mechanistic hypotheses for disease processes; 2) comprehensive in vivo and ex vivo
biomechanical testing to quantify the mechano-responsiveness, quality, and strength of the skeleton under
physiological and pathological conditions; and 3) banking and access to human tissue samples from hip
replacement surgeries and bone marrow cells with their associated clinical data from patients with various
conditions. This is a novel component that will expand the translational research opportunities in the Center for
Musculoskeletal Disease Research (CMDR) for Project Leaders, CMDR faculty, and eventually additional
researchers at the University of Arkansas for Medical Sciences (UAMS) and affiliated institutions. The core will
be essential to accomplish the goals of each Phase 2 research project. Core C will extensively interact with the
other cores of the CMDR by providing histological and biomechanical analysis for new mouse models created
by the Genetic Mouse Model Core (Core B), working with the Bone Imaging Core (Core D) for biomechanical
analysis and providing samples for histomorphometric analysis, and collaborating with the Bioinformatics Core
(Core E) for developing spatial transcriptomics. Overall, the Histology, Biomechanics, and Human Tissue Core
provides unique and essential services and thereby significantly expands the musculoskeletal research
infrastructure at UAMS and its affiliates.

## Key facts

- **NIH application ID:** 10814744
- **Project number:** 5P20GM125503-07
- **Recipient organization:** UNIV OF ARKANSAS FOR MED SCIS
- **Principal Investigator:** Jinhu Xiong
- **Activity code:** P20 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $232,228
- **Award type:** 5
- **Project period:** 2018-02-16 → 2028-01-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10814744

## Citation

> US National Institutes of Health, RePORTER application 10814744, Histology, Biomechanics, and Human Tissue Core (5P20GM125503-07). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10814744. Licensed CC0.

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