Abstract An essential component of Phase III CoBRE funding for the Center for Cancer Biology Research (CCBR) is support of the Histology & Imaging Core (Core B). The Imaging Core, established in 2007, and the Molecular Pathology Core, established in 2011, were both extensively utilized not only by CCBR investigators but also those at Sanford Research at large as well as investigators from regional institutions. Their merging to establish the Histology & Imaging Core in 2018, united these highly utilized cores to provide more efficient support from staff offering extensive expertise in these areas. In addition to providing state-of-the-art equipment, the Histology & Imaging Core staff provide a wide array of services (standard and custom) that afford investigators high quality data without the investment of their time for troubleshooting or obtaining expertise in the technique. Continued CoBRE support for this Scientific Core as it transitions to a schedule of fee-for-services will provide the necessary time to obtain self-sustainability. As this Core expands its services, it will continue developing a larger collection of clients. In this way, self-sufficiency will be attained. Already, the reputation of the Core's quality work and quick turnaround has expanded regionally resulting in its increased usage. CoBRE funding through Phase III will ensure successful self-sustainability will be obtained.