This is the 1st renewal of the Brown Respiratory Research Training Program (BRRTP). The overall goal of the program is to provide predoctoral candidates and postdoctoral fellows training in the pathobiology and/or outcomes, prevention, and epidemiology as it relates to pulmonary/ critical care/ sleep disorders. This unique program at Brown University fosters close interactions and collaborations between trainees and faculty from multiple disciplines and training backgrounds in both the medical school and across all the teaching hospitals in the Brown University system. We propose to continue to train 4 predoctoral and 4 postdoctoral trainees per year. The predoctoral trainees will be enrolled in PhD programs, while the postdoctoral trainees will have completed their PhD, MD, or MD/PhD degrees. Individuals completing this program will be well positioned to contribute to understanding of lung diseases, to develop independent research careers, to translate advances in basic, clinical, and health services research to clinical applications and teaching, and to address health issues critical to society. The predoctoral training program continues to focus on the pathobiology of respiratory diseases and to capitalize on strengths in the areas of infection and immunity. In this renewal, we have added pulmonary vascular biology to the pathobiology focus, enhancing faculty and trainee participation and enlarging the range of research interests. The postdoctoral training program consists of two inter-related tracks —pathobiology of respiratory diseases plus health services/ outcomes and epidemiology of respiratory diseases.