HERCULES: INTEGRATED HEALTH SCIENCES FACILITY CORE – SUMMARY Partnering with HERCULES Cores that define and apply (Community Engagement Core, CEC), enable and interpret (Environmental Health Data Sciences Core, EHDSC), innovate (Pilot Project Program, PPP), and coordinate and evaluate (Administrative Core), the Integrated Health Sciences Facility Core (IHSFC) will operationalize translational research on the exposome. Specifically, the IHSFC will: deliver targeted analytical support to quantify exposures to known hazardous environmental agents, environmentally-important clinical biomarkers, and suspect chemicals (Aim 1); provide untargeted analytical support for global study of known and unidentified endogenous and exogenous chemicals associated with environmental exposures or adverse health outcomes (Aim 2); offer comprehensive clinical and population research services to Center-based scientists (Aim 3); and catalyze applied translational research on the exposome in humans and in communities of interest (Aim 4). Drawing on the strong foundation developed during the first two rounds of Center funding, the IHSFC will expand in several key areas: 1) with the very successful programs in targeted and untargeted analytical support, we will focus in Aims 1 and 2 on new innovations within our laboratory and analytical methods; 2) with research support structure that bridges clinical and population-based research in Aim 3, we will emphasize outreach and broad utilization of the IHSFC; and 3) building on tested exposomics tools and technology, we will emphasize and prioritize a broader vision of translational research on the exposome in Aim 4. In doing so, the IHSFC will promote discovery in established and emerging environmental health concerns and will foster development, implementation, and assessment of interventions to address these concerns. IHSFC activities will be driven by the HERCULES exposome and translational research frameworks that incorporate community knowledge and concerns. The IHSFC team has established national and international research leadership in exposure science, chemistry, quantitative biology, metabolomics, and clinical and population studies in broad environmental health areas. Within the Center, the IHFSC will work closely with the CEC to enhance bidirectional understanding of exposome-related concepts, research, and their importance in human health among HERCULES Member and community partners. The IHSFC will continue its key role as a driver of the EHDSC, specifically to deliver data, enhance EHDSC utilization, and facilitate development of exposome-related tools. The IHSFC will support investigators seeking to submit proposals to the PPP and will support PPP-funded novel research projects that facilitate translation and integration of exposome-related research data, tools and concepts. Moreover, the IHSFC will work closely with the Administrative Core in translational research planning, to enhance training opportunities, and...