# Translation of a Bismuth-Gadolinium Nanoparticle for MR-guided Radiation Therapy

> **NIH NIH R01** · DANA-FARBER CANCER INST · 2024 · $566,253

## Abstract

Project Summary
Recent preclinical and clinical results have demonstrated the safety and efficacy of
nanoparticle-amplified radiation therapy. In parallel, MR-guided radiation therapy is an
emerging paradigm that would benefit from specific contrast agents. This Academic-
Industrial Partnership will leverage these current trends by designing, developing and
rigorously testing a novel nanoparticle for MR-guided radiation therapy. Our supporting
data consists of extensive physical and biological characterization of gadolinium and
bismuth-gadolinium based nanoparticles, including in vivo biodistribution, imaging and
therapy results in multiple tumor models. In this project, we will develop and optimize a
direct high-yield synthesis process for bismuth-gadolinium nanoparticles and perform
extensive toxicity and therapy evaluation in a translational model under clinical delivery
schedules and conditions. Our innovative and highly translatable imaging and therapy
concept is compatible with current and emerging clinical practice and could offer a
substantial clinical benefit with minimal patient risk.

## Key facts

- **NIH application ID:** 10815534
- **Project number:** 5R01CA240804-05
- **Recipient organization:** DANA-FARBER CANCER INST
- **Principal Investigator:** Ross I. Berbeco
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $566,253
- **Award type:** 5
- **Project period:** 2020-03-01 → 2026-02-28

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10815534

## Citation

> US National Institutes of Health, RePORTER application 10815534, Translation of a Bismuth-Gadolinium Nanoparticle for MR-guided Radiation Therapy (5R01CA240804-05). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10815534. Licensed CC0.

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