ABSTRACT (Integrated Health Sciences Core) The mission of the Michigan Center on Lifestage Environmental Exposures and Disease (M-LEEaD) is to accelerate research that defines the impact of environmental exposures during vulnerable life stages and promote translation of research findings to improve clinical and public health interventions for the mitigation of human disease. In support of this mission, M-LEEaD’s Integrated Health Sciences (IHS) Core facilitates multi-directional interaction among environmental health scientists, clinical researchers and practitioners, quantitative research scientists, and environmental health practice professionals, leading to enhanced translation of research findings into public health practice. In this competing renewal, we build on successes in strengthening connections between research and community and practice needs, in partnership with the Community Engagement Core (CEC). The IHS Core goals are: to identify and facilitate access to human and animal biobanks, to promote multi-directional translational research, to ensure quality of research designs, to provide statistical support, and to link investigators with services provided by M-LEEaD cores and other UM resources. The IHS Core offers cutting-edge statistical methods to advance environmental health research and facilitates translation to practice and policy. The IHS Core provides a critical linkage function promoting translational scholarship and multi- directional stakeholder partnerships, through close coordination with CEC. Specifically, the IHS Core aims to 1) provide Center investigators with high-quality study design, laboratory, and repository protocols, and statistical support for advancing environmental health research; 2) educate and train Center investigators, staff, students and practitioners in study design, community-engaged research, laboratory practice, curation of bio-repositories, and statistical methods through seminars and workshops; 3) promote interdisciplinary collaborations that foster translational research; 4) maintain and update the searchable, web-based Kiosk to provide information on human and animal studies and core services of the M-LEEaD Center; and 5) catalyze multi-directional partnerships, in coordination with CEC, with practitioners and community members to connect research on environmental risk factors to locations where people live, work, and play through-out the life-course. The IHS Core provides center members with both basic/routine statistical support and cutting-edge statistical methods to advance environmental health. The IHS Core facilitates the M-LEEaD translational research vision by hosting an environmental statistics and an environmental health practice workshop series. Dissemination of workshops occurs via the M-LEEaD website, and the IHS Core has achieved specific impact in addressing environmental health concerns in Michigan (e.g., PFAS/PBB) by offering presentations, webinars and symposia attended by s...