ABSTRACT The Data Management and Analysis Core (DMAC) is designed to provide a shared resource for data management and analysis across projects, and to facilitate the integration and sharing of data and analytic resources. By centralizing these activities, we will ensure the integrity of the data produced by each project, create efficiencies through sharing of data and analytic resources, and provide biostatistical consultation that incorporates an in-depth knowledge of pulmonary fibrosis etiology. This strategy will also allow us to coordinate study design and data management issues, leading to a more coherent approach to data analysis, as well as significant cost savings The Core Lead (Peljto) will supervise a team that is experienced in the conduct of studies involving multidisciplinary research. The team also has the skill set required to manage complex issues of study design, multifaceted database management, genomics, and broad quantitative methods. The key activities of the DMAC will be 1) providing study design consultation and refinement, 2) providing a secure, central repository and quality control for data generated, 3) conducting biostatistical and bioinformatics analyses to test proposed hypotheses 4) facilitating integration and sharing of Project data and analytic resources. These activities will directly serve all four projects through study design consultation and analysis. In addition, the DMAC will work closely with Cores B and C to transfer, annotate, and store data and digital images generated for each Project. Finally, this Core will coordinate with the Administrative Core, as it provides the administrative and organizational structure to support this Program, and will receive direction from the Administrative Core. This Core will interact with the Administrative Core and Project Investigators at regular meetings, such that each week Dr. Peljto and appropriate DMAC members will meet with either an individual Project team or the entire Program. These activities of the Core will assist all of the Projects and the Administrative Core in fulfilling their research, reporting, and resource sharing goals and obligations