# Animal and Biostatistics Core

> **NIH NIH P01** · UNIVERSITY OF SOUTHERN CALIFORNIA · 2023 · $240,456

## Abstract

Abstract 
The Animal and Biostatistics Core will work directly with Project Leaders to design, plan, monitor and interpret 
all animal experiments, as well as, provide specific mouse models and standardized experimental protocols in 
support of the overall program's common goals: 1) understand how age and genetic background modulate the 
effects of fasting-mimicking diets (FMD) and protein restriction cycles (PRC) on longevity and healthspan, 2) 
study the mechanisms of FMD-, PRC-dependent cellular protection, regeneration and rejuvenation in the 
hematopoietic and nervous systems, 3) understand the link between FMD and PRC, GH-IGF-1, mTOR and 
humanin to test the hypothesis that this mitochondrial peptide is a PFC/PRC mediator with the potential to 
serve as a fasting/protein restriction mimetic, 4) study the regulation of the cysteine gamma lyase-dependent 
production of the gas H2S, negatively regulated by GH/IGF-1-mTOR, and test the hypothesis that H2S is a 
mediator of the protective effects of FMD on resistance to hepatic ischemia reperfusion injury and 
chemotherapy-induced toxicity to hematopoietic stem cells. The core provides an integrative framework for 
assessment of common outcomes across the individual projects needs. 
Aim 1. Design, plan and monitor animal experimental procedures as directed by Project Leaders. Studies are 
designed to achieve sufficient power/sensitivity to meet the stated objectives. All experimental procedures 
performed on mice are standardized and performed by Core B to ensure consistent assessment across all 
projects. These include: A) Longevity, B) Healthspan (Metabolic/Cognitive and Cellular/Molecular), C) Stress 
resistance and Mechanistic studies, D) Tissue collection/distribution. 
Aim 2. Coordinate animal use for program. All animals obtained or generated through Core B will be housed in 
the state-of-the-art vivarium facility in the Ray R Irani Hall at USC. Individual dedicated animal holding rooms 
for the exclusive use of either breeding, longevity or stress resistance will ensure consistency of biological 
environment, noise control and security across all studies.

## Key facts

- **NIH application ID:** 10816719
- **Project number:** 3P01AG055369-05S1
- **Recipient organization:** UNIVERSITY OF SOUTHERN CALIFORNIA
- **Principal Investigator:** TODD E MORGAN
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2023
- **Award amount:** $240,456
- **Award type:** 3
- **Project period:** 2018-02-15 → 2024-01-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10816719

## Citation

> US National Institutes of Health, RePORTER application 10816719, Animal and Biostatistics Core (3P01AG055369-05S1). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10816719. Licensed CC0.

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