Project Summary /Abstract This is a proposal to continue the Pediatric Critical Care Trauma Scientist Development Program (PCCTSDP) as a national program to support research career development for young faculty in pediatric critical care and pediatric trauma surgery. The goal of the PCCTSDP is to increase the number of highly trained, successfully funded and sustainable physician scientists in pediatric critical care and trauma surgery, who will do research to enhance the scientific understanding of the pathophysiology and clinical management of critical illness and trauma, with emphasis on long-term consequences of critical illness and injury for children and families. In the first nineteen years of the program, 61 PCCTSDP awardees (Scholars) have been appointed. Scholars have received 37 K08 or K23 awards, and 39 R01- equivalent awards with many achieving other federal and foundation funding. Scholars are selected by a National Advisory Committee (NAC) consisting of outstanding pediatric and trauma surgeon scientists who are leaders in the field. Two to three new Scholars are appointed annually. Applicants will identify an outstanding scientific mentor at their own institution, and will be sponsored by their department chair. Each Scholar will spend 2 years in an intense research training environment in basic, clinical or translational research, with a minimum of 75% protection from non-research responsibilities (Phase I). In the subsequent 3 years (for a total of 5 years), Scholars must be financially supported by their institutions to continue to have at least 50% - 75% protection to transition into independent investigators (Phase II). Scholars are expected to apply for their own extramural funding in the form of a K or R level award in the first 18 months of the K12 award. The PCCTSDP conducts an annual scientific retreat during which Scholars will interact with the NAC members and NIH staff, present their scientific work, discuss their career development plans and progress, and participate in selected workshops on faculty development, grant writing, rigor and reproducibility and other relevant topics designed to enhance core competencies in research training. Fellows and junior faculty who are underrepresented in medicine and those from IDeA States may apply to be Diversity or IDeA Fellows at the retreat. By providing extended training and protected time to develop outstanding skills in these young faculty, the PCCTSDP will continue to increase the pool of skilled investigators in pediatric critical care and trauma.