Project Summary Ending the HIV Epidemic (EHE): A Plan for America has prioritized the vital role of collaboration across Department of Health and Human Services federal agencies as well as state and local jurisdictions in order to achieve the ambitious goals of a 75% reduction of new HIV cases by 2025, and a 90% reduction by 2030. Implementation Science, although squarely anchored to the research enterprise, is uniquely positioned to achieve cross-agency coordination and collaboration due to the intrinsic focus on context, spanning community, clinical, and public health environments. Leveraging extant National Institutes of Health (NIH) HIV research resources afforded by the CFAR and AIDS Research Centers (ARC) programs, a multisite Implementation Science Hub network was established in FY 2020, with a data coordinating center. The University of Alabama at Birmingham (UAB) CFAR Implementation Science Hub is fully committed to building upon the foundation established during the inaugural three years of funding as part of this synergistic, integrated HIV implementation science community. This will be achieved via the provision of technical assistance, coaching, training, and consultative services to assigned EHE supplement awardees as a Regional Consultation Hub (RCH) and coordination and collaboration with the Coordination, Consultation and Data Management Center (CCDMC), with added value via the engagement of scientists pursuing and conducting NIH funded, EHE aligned implementation science grants at UAB and/or via national inter-CFAR networks (e.g., CFAR Network of Integrated Clinical Systems (CNICS)). Our interdisciplinary UAB CFAR IS hub team is committed to accelerating innovation in HIV community engagement, health equity, prevention, healthcare delivery, treatment, and care. Beyond supporting investigators on scientific matters pertaining to IS research designs, frameworks, measures, and evaluation, we have provided vital guidance with pragmatic issues pertaining to academic-public health partnerships, collaboration and publications, community engaged science, and regulatory and compliance considerations, paramount to the success of projects conducted with non-traditional clinical, community and public health research partners. Proposed activities are well aligned with NIH HIV/AIDS Research Priorities, most notably substantively supporting research in the cross-cutting areas of “health disparities, behavioral and social sciences research, epidemiology, information dissemination, implementation sciences, and training,” and will be achieved via five specific aims: Aim 1: Coaching is centered on developing a project development plan with each supplement / project PI, Aim 2: Consultation systematically includes guidance on application of the IS logic model and identification of appropriate outcome measures for each project utilizing the IS cross walk, Aim 3: Dissemination includes guidance on scholarly products informed by the project development...