# Development of a highly sensitive and specific POCT testing asthma triggering allergic IgE

> **NIH NIH R43** · ALLERDIA INC · 2023 · $55,565

## Abstract

Summary of Administrative Supplement
The overall goal of the parent project is to develop and eventually commercialize a novel point-of-care test
capable of rapidly and highly accurately detecting allergic IgE to environmental allergens as an approach to
promote healthy living and reduce minority health disparities. This administrative supplement application is
intended to enhance the diversity of the research and entrepreneurial workforce by supporting a candidate,
Christian Lapitan, to establish a standardized procedure to ensure the consistent product quality of the reverse
lateral flow immunoassay (R-LFIA) rapid test device. The research project of this administrative supplement
for the candidate is to express, purify, characterize, and employ the recombinant allergens derived from
bacteria (E. coli) to replace the crude allergen extracts as an allergen source for preparation of allergen-gold
nanoparticle conjugates to achieve consistent and accurate test results with R-LFIA. Enhancement of research
and entrepreneurial capability for the candidate is another major purpose of this diversity supplement. To do
so, the applicant company Allerdia has developed a mentoring plan; a plan for mentor-candidate interactions;
and a plan for business and entrepreneurship enhancement.

## Key facts

- **NIH application ID:** 10817658
- **Project number:** 3R43HL167289-01S1
- **Recipient organization:** ALLERDIA INC
- **Principal Investigator:** Ke Zhang
- **Activity code:** R43 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2023
- **Award amount:** $55,565
- **Award type:** 3
- **Project period:** 2023-02-01 → 2024-01-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10817658

## Citation

> US National Institutes of Health, RePORTER application 10817658, Development of a highly sensitive and specific POCT testing asthma triggering allergic IgE (3R43HL167289-01S1). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10817658. Licensed CC0.

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