# A stalled chromatin regulatory network that mediates the oncogenic activity of Meningioma-1

> **NIH NIH R01** · CHILDREN'S HOSP OF PHILADELPHIA · 2024 · $416,556

## Abstract

PROJECT SUMMARY
High expression of the transcriptional co-activator Meningioma-1 (MN1) is common in AML, and associated
with a poor prognosis. Forced expression of MN1 in murine hematopoietic progenitors induces an aggressive
leukemia. We recently discovered that the primary interaction partner of MN1 is the BAF nucleosome-
positioning complex. MN1 stabilizes BAF on chromatin. MN1 binding is associated with sustained active
enhancer chromatin at enhancers regulating a hematopoietic stem/progenitor program. We hypothesize that
MN1 stabilizes promoter-enhancer contacts at these sites through a BAF dependent mechanism. The goal
of this project is to uncover the molecular mechanism of MN1-mediated leukemic transformation. A better
understanding of how MN1 causes leukemia may identify opportunities for targeted therapies in a patient
population who is failing conventional AML therapy.

## Key facts

- **NIH application ID:** 10818372
- **Project number:** 5R01CA262260-03
- **Recipient organization:** CHILDREN'S HOSP OF PHILADELPHIA
- **Principal Investigator:** KATHRIN M BERNT
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $416,556
- **Award type:** 5
- **Project period:** 2022-04-01 → 2027-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10818372

## Citation

> US National Institutes of Health, RePORTER application 10818372, A stalled chromatin regulatory network that mediates the oncogenic activity of Meningioma-1 (5R01CA262260-03). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10818372. Licensed CC0.

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