# Multi-omic Predictors of Renal Function among HIV-infected Individuals of African Ancestry

> **NIH NIH R01** · EMORY UNIVERSITY · 2023 · $100,000

## Abstract

PROJECT SUMMARY/ABSTRACT
Although antiretroviral therapy (ART) results in successful suppression of HIV and a decrease of AIDS
progression, people living with HIV (PLWH) experience a higher incidence of chronic diseases and shorter
expectancy of life. Chronic kidney disease (CKD), which emerged as a common complication of both HIV
infection and its treatment, has been a critical cause of shortened life span in PLWH. The pathogenesis of HIV-
related CKD is multifactorial, linked to direct exposure to HIV viremia, superinfections, the systemic immune
response to infection and ART regiments, as well as to traditional CKD risk factors. Both genetic and
environmental factors play a role in the development and progression of CKD, and affect biological functions
and pathways at multiple molecular levels. Research continues to suggest that epigenetic changes may play a
pivotal role in the pathology of CKD and HIV infection. Integrated with other molecular layers, such as host
genome and transcriptome, epigenome can mediate genetic, environmental and physiological effects, and can
potentially influence kidney function. However, the epigenomic and multi-omic impacts on kidney function and
disease have not been investigated at population level, particularly among people of African ancestry who
experience high burden of CKD but underrepresented in multi-omics research. We will identify and replicate
epigenetic predictors of kidney function using a longitudinal epigenome-wide approach (Aim 1). We will
also examine genetic factors associated with epigenetics and kidney disease to elucidate mediation,
modification and causal inference between genetics, DNAm and kidney function (Aim2). We will conduct
integrative multi-omics analyses to genes, pathways and molecular system related to eGFR (Aim 3).
Knowledge learned from this study will potentially improve long-term clinical outcomes of PLWH, promote
precision medicine for HIV treatment, and support high priority topics in HIV/AIDS research.

## Key facts

- **NIH application ID:** 10818685
- **Project number:** 3R01DK125187-04S1
- **Recipient organization:** EMORY UNIVERSITY
- **Principal Investigator:** Vincent Charles Marconi
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2023
- **Award amount:** $100,000
- **Award type:** 3
- **Project period:** 2020-08-01 → 2024-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10818685

## Citation

> US National Institutes of Health, RePORTER application 10818685, Multi-omic Predictors of Renal Function among HIV-infected Individuals of African Ancestry (3R01DK125187-04S1). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10818685. Licensed CC0.

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