# Core P: Molecular and Cellular

> **NIH NIH P30** · UNIVERSITY OF CALIFORNIA, SAN DIEGO · 2024 · $597,927

## Abstract

Core P: Molecular and Cellular Immunology (MCI) Project Summary/Abstract
The mission of our new Molecular and Cellular Immunology (MCI) Core is to support our Center’s research
priorities - prevent new infections, optimize care, find a cure, and promote health equity for all - by facilitating
highly technological research. The MCI Core is a laboratory-based service Core designed to support HIV
research involving broad characterization of the cellular and molecular milleu at multiple levels. The MCI Core
provides an easy and efficient path for SD CFAR investigators to incorporate flow cytometry, genomics, and
single-cell -omics technologies into their research activities. The MCI Core provides data processing support to
its users, and ensures data integrity and reproducibility. In addition to supporting the funded projects of
established investigators, the MCI Core strives to provide the scientific environment and material resources to
enable emerging investigators to apply different state-of-the-art technologies to their developmental projects and
to encourage established investigators to initiate innovative pilot or collaborative studies.
The specific aims of the MCI Core are:
1. Assays: To provide expertise and develop new applications in cell phenotyping, sorting, gene expression
 quantification and multi–omics single-cell profiling based on the research needs of SD CFAR investigators.
2. Computational biology: To process, collate, format and analyze flow cytometry, gene expression and multi-
 omics single-cell data, and develop new analytical pipelines as needed by the users, working closely with
 the BAM Core.
3. Training: To provide training in MCI Core technological methods, experimental design and data analysis for
 the advancement and intellectual growth of the next generation of HIV researchers.
4. Quality assurance: To monitor and ensure biosafety and the integrity and reproducibility of all generated
data.
The MCI Core is organized into three units, Flow Cytometry, Genomics and Single-Cell -Omics, each specializing
in its corresponding methodological area. Each unit is led by accomplished experts with coordinated
communications. To provide the most useful and up-to-date services, the MCI Core undergoes a rigorous
strategic planning process through user feedback, surveys, evaluating guidance from the both the scientific and
impacted local communities in meetings and presentations as well as incorporating recommendations from
internal and external advisory committees and reviews. Immediate challenges that are addressed in this
application include: 1) Expanding single-cell –omics services; 2) Facilitating access to flow cytometry and –omics
applications under one roof to enable uninterrupted work flow; 3) Expanding data processing support; and 4)
Improving web-based ordering and the utilization and tracking system.

## Key facts

- **NIH application ID:** 10819198
- **Project number:** 5P30AI036214-30
- **Recipient organization:** UNIVERSITY OF CALIFORNIA, SAN DIEGO
- **Principal Investigator:** Dennis R. Burton
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $597,927
- **Award type:** 5
- **Project period:** 1997-04-01 → 2028-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10819198

## Citation

> US National Institutes of Health, RePORTER application 10819198, Core P: Molecular and Cellular (5P30AI036214-30). Retrieved via AI Analytics 2026-05-29 from https://api.ai-analytics.org/grant/nih/10819198. Licensed CC0.

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