PROJECT ABSTRACT The goals of the COBRE Center for Applied Immunology and Pathological Processes (CAIPP) are to establish a nationally recognized advanced research and training program to understand immunological contributions in various disease states and facilitate the development of junior faculty research programs to achieve major independent research funding. Application of networking analysis and modeling approaches to immunological questions is capable of predicting genetic mediators and modeling immune outcomes in response to various pathogens and disease states. The Center for Applied Immunology and Pathological Processes proposes to develop a Modeling Core (Core B) to support the CAIPP research activities. The goals of the Modeling Core are to provide access to technical and scientific expertise that advances individual COBRE investigator projects. The Modeling Core will bring needed infrastructure to drive hypotheses, expedite publications, and enhance our competitiveness for extramural funding. Education and training initiatives will increase the systems-based bioinformatics knowledge at LSUHSC-S and inspire others to pursue bioinformatics in their research.