# Data and Analytical Core

> **NIH NIH P50** · PRINCETON UNIVERSITY · 2024 · $329,000

## Abstract

The thalamus plays a critical role in attention, cognitive control and decision-making, serving as
an important hub of temporal integration and coordination across nodes of large-scale cortical
and subcortical networks. Identification of functional connectivity between thalamocortical
networks across tasks and species is key to understanding complex thalamic computation at
both single-unit and population levels. The Data and Analytic Core of the Conte Center project
will contribute to attaining the Center objectives in multiple directions. We will establish a data
curation/sharing pipeline and develop advanced statistical and data-driven machine learning
tools for analyses of various sources of neural recordings from higher-order thalamic nuclei
(especially the mediodorsal thalamus and pulvinar) in both nonhuman and human primates. In
Aim 1, we will establish a semi-automated human-in-the-loop pipeline for data curation,
documentation, and sharing. In Aim 2, we will develop multivariate data analysis toolkits with
open-access software and documentation. In Aim 3, we will develop integrated tools to test the
role of higher order thalamic nuclei in regulating thalamo-cortical functional connectivity. The
Data and Analytic Core will collaborate with other project PIs and provide strong support for
data sharing, analysis and tool development for both animals’ electrophysiological and humans’
neuroimaging data. Accomplishment of these aims will advance our understanding of thalamo-
cortical communications in healthy and diseased brains.

## Key facts

- **NIH application ID:** 10819546
- **Project number:** 5P50MH132642-02
- **Recipient organization:** PRINCETON UNIVERSITY
- **Principal Investigator:** Zhe Sage Chen
- **Activity code:** P50 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $329,000
- **Award type:** 5
- **Project period:** 2023-04-03 → 2028-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10819546

## Citation

> US National Institutes of Health, RePORTER application 10819546, Data and Analytical Core (5P50MH132642-02). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10819546. Licensed CC0.

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