PROJECT SUMMARY. CERCA DE TI (“Close to You” in Spanish) is a new pharmacy chain-based PrEP program that will leverage CVS Health services and infrastructure to help Latinx learn about PrEP, decide if PrEP is relevant for their lives, access PrEP, and sustain PrEP use. This project addresses the EHE Pillar “Protect.” The goals of this EHE pilot study are to explore and plan the groundwork needed for the future implementation of CERCA DE TI, and to determine if the necessary resources are available for effective future implementation. This application is supported by 5+ years of ongoing collaborations between Dr. Kanamori and CVS Health during which we implemented a pharmacy chain-based recruitment program to support a PrEP program implemented by our partner Latinos Salud. To date, this program has provided PrEP to a total of 1,581 clients and currently has 581 PrEP clients. Building on this success recruiting PrEP clients through CVS Health venues, we are now proposing to develop a one-stop-shop PrEP program promoted and offered by CVS Health. CERCA DE TI will include five implementation strategies from the Expert Recommendations for Implementing Change (ERIC) project: 1) Increase Demand. PrEP information available at different CVS Health companies will be tailored to different demographics: Farmacia Navarro (Spanish speaking clients), TARGET (women and families), CVS stores (general population), and CVS Health’s MinuteClinic, Clinics in CVS HealthHUB, and CVS Health Virtual Care (clients engaged in health care). 2) Promote Adaptability. CERCA DE TI will add a customer-centric, pharmacy-based PrEP program which reflects cultural norms, needs and preferences of different CVS Health clientele. 3) Streamline Recruitment and Enrollment. A one- stop-shop PrEP program will be offered at CVS Health’s MinuteClinic, Clinics in CVS HealthHUB, and CVS Health Virtual Primary Care. 4) Identify and Prepare Champions. CERCA DE TI will capitalize on CVS Health executives, pharmacists, nurse practitioners, and store staff members. And 5) Tailor Strategies and Consumer Engagement. CVS.com and the CVS Pharmacy app will promote PrEP information and new shopping experiences. Our project’s aims are: AIM 1: Evaluate Consolidated Framework for Implementation Research factors important for the implementation and sustainability of CERCA DE TI (outer setting, inner setting, characteristics of intervention, and process characteristics). We will implement mixed methods interviews with executives and staff. AIM 2: Identify modifiable factors within the outer setting and characteristics of individuals for successful delivery of PrEP information and a one-stop-shop PrEP program at CVS Health. We will implement PhotoVoice with clients. AIM 3: Refine ERIC implementation strategies through an Evidence Based Quality Improvement (EBQI) process. With 85% of the U.S. population living less than 10 miles from a CVS Pharmacy venue, CERCA DE TI has the potential to scale-up to a national...