# A Synchrotron Radiation Structural Biology Resources

> **NIH NIH P30** · STANFORD UNIVERSITY · 2024 · $491,933

## Abstract

Synchrotron radiation (SR) is an extremely bright and tunable x-ray source that enables forefront
research in structural molecular biology (SMB). The goal of “A Synchrotron Structural Biology
Resource" at the Stanford Synchrotron Radiation Lightsource (SSRL) is to provide users access
to an integrated, mature SMB Resource with state-of-the-are synchrotron beam line facilities for
macromolecular crystallography, x-ray absorption/emission/imaging spectroscopy and small
angle x-ray scattering/diffraction, that form the three Resource Technical Operations Cores.
Special emphasis is to create streamlined user access, provide dedicated user support and
services, to train users, and to perform outreach on the scientific benefits of the capabilities of
these specialized, yet mature facilities to the biomedical research community. Multiple innovative
access mechanisms will be provided, that will include both single- and multiple-technique
approaches to access the Cores, based on a transparent and robust external peer-review
process. A multifaceted training and outreach program will include individual training, workshops,
summer schools, on-the-road, and support clinic segments by experienced science and technical
staff. A Resource web portal will provide streamlined scientific, technical, training, outreach and
administrative material and other relevant information. A principal aim is to optimize and maintain,
for reliable and forefront performance, experimental facilities and instrumentation, detectors,
software and computing and network capabilities on the SMB Resource’s 8+ beam lines at SSRL,
capitalizing on the high SR x-ray performance of SSRL’s 3rd generation storage ring SPEAR3,
and at the MFX station at LCLS. A multi-facility proposal mechanism will facilitate access to
complementary Cryo-EM and LCLS stations on-site at SLAC. With a specialized focus on user
training, support and service, the SMB Resource will enable the scientific success for challenging
and routine projects in the biomedical sciences.

## Key facts

- **NIH application ID:** 10820528
- **Project number:** 5P30GM133894-05
- **Recipient organization:** STANFORD UNIVERSITY
- **Principal Investigator:** Thomas Michael Weiss
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $491,933
- **Award type:** 5
- **Project period:** 2020-06-01 → 2025-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10820528

## Citation

> US National Institutes of Health, RePORTER application 10820528, A Synchrotron Radiation Structural Biology Resources (5P30GM133894-05). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10820528. Licensed CC0.

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