# Pharmacology of Stimulant Choice

> **NIH NIH R01** · VIRGINIA COMMONWEALTH UNIVERSITY · 2024 · $349,313

## Abstract

This new R01 application proposes a systematic series of experiments focused on drug-choice procedures in
male and female rats to evaluate the muscarinic acetylcholine receptor (mAChR)1 agonist VU0364572 as a
candidate medication for treatment of cocaine and methamphetamine use disorder. This application is founded
on the premise that stimulant use disorder in humans can be studied using preclinical assays of drug-vs-food
choice that model clinical aspects of behavioral misallocation and decision making between concurrently
available drugs and an alternative nondrug reinforcer. We propose to determine 1) VU0364572 effects on
cocaine-food and cocaine-social choice, 2) VU0364572 effects on methamphetamine-food and
methamphetamine-social choice, and 3) VU0364572 effects on nucleus accumbens and prefrontal cortex
dopamine release using dLight.

## Key facts

- **NIH application ID:** 10821320
- **Project number:** 5R01DA055825-02
- **Recipient organization:** VIRGINIA COMMONWEALTH UNIVERSITY
- **Principal Investigator:** Matthew L Banks
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $349,313
- **Award type:** 5
- **Project period:** 2023-04-15 → 2028-02-29

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10821320

## Citation

> US National Institutes of Health, RePORTER application 10821320, Pharmacology of Stimulant Choice (5R01DA055825-02). Retrieved via AI Analytics 2026-05-27 from https://api.ai-analytics.org/grant/nih/10821320. Licensed CC0.

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