# Administrative Core (Core A)

> **NIH NIH P01** · UT SOUTHWESTERN MEDICAL CENTER · 2024 · $125,367

## Abstract

Heart failure progression is a complex biological process that is precipitated by the maladaptive
myocardial response to injury, compounded by failure of the adult heart to replace lost or damaged
cardiomyocytes. Conceivably, identifying common pathways that regulate these two seemingly
unrelated processes would profoundly impact therapeutic strategies to prevent, and even reverse heart
failure progression. Numerous observations by members of the proposed consortium and others support
the notion that the endogenous capacity of the neonatal mammalian heart to proliferate fades in the
early postnatal life as a switch from hyperplastic to hypertrophic growth of cardiomyocytes takes place.
Members of the proposed consortium and others have also previously demonstrated that mechanisms
linked to activation of the immune response may play a role in cardiomyocyte hypertrophy, death,
healing and even stimulation of new cardiomyocyte generation. The current proposal brings together
several groups with significant expertise in myocardial remodeling, regeneration and immunology with
the overall goal of determining the role of immune response signaling in regulation of cardiac growth,
healing and regeneration. Indeed, the immune response has taken center stage in the past several
years as a primary determinant of both healthy cardiac aging and healing after injury, as well as a
determinant of chronic disease states when it is inappropriately regulated. Thus, this Program will
investigate a frontier and emerging area of scientific investigation involving the intersection between the
immune system and the myocardium. The Administrative Core (Core A) of the proposed Program
Project will provide critical administrative and logistical services of the 4 Projects as well as the two other
cores, Core B and Core C. Through the highly interrelated series of experiments proposed in our four
Projects, and supported by the activities of an Administrative Core (Core A), Immunology and
Physiology Cores (Cores B, and C), we aim to answer questions that are crucial for understanding the
role of immunity in the regulation of cardiac homeostasis and pathology. Together, these studies will
test a paradigm changing hypothesis that the immune system is a critical regulator of cardiac growth
and repair. The Administrative Core will be housed at University of Texas Southwestern Medical Center,
Division of Cardiology. Core A will be led by Dr. Hesham Sadek and will be tasked with providing PIs
and key personnel with the administrative and logistic support needed to achieve the goals of the project.
Core A will provide research administrative support, fiscal and intellectual property support, facilitate
communications, and provide statistical consultation for the entire Program Project. As such Core A will
play a vital role as the operational manager of the Program Project.

## Key facts

- **NIH application ID:** 10821351
- **Project number:** 5P01HL160488-02
- **Recipient organization:** UT SOUTHWESTERN MEDICAL CENTER
- **Principal Investigator:** Hesham Sadek
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $125,367
- **Award type:** 5
- **Project period:** 2023-04-05 → 2025-02-28

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10821351

## Citation

> US National Institutes of Health, RePORTER application 10821351, Administrative Core (Core A) (5P01HL160488-02). Retrieved via AI Analytics 2026-05-27 from https://api.ai-analytics.org/grant/nih/10821351. Licensed CC0.

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