PROJECT SUMMARY This application is to request support for the 2024 Gordon Research Seminar (GRS; March 16-17) and Conference (GRC; March 17-22) on Myelin to be held in Ventura, California, USA. The goal of these conferences is to provide an active forum for the exchange of results at the cutting edge of myelin development, physiology, pathology, and treatment. This meeting uniquely focuses on central and peripheral myelin and is timely given the growing interest in myelin biology and human disease and major advances since the last meeting in 2022. We have chosen as a theme for this conference “Dynamism and Life-Long Plasticity of Myelin Producing Cells in Health and Disease” to reflect the major shift over the past few years from considering myelin as a relatively static structure to the new view of myelin as a dynamic structure throughout the lifetime of the organism. This dynamism and the plasticity of Schwann Cells and oligodendrocytes impacts normal myelin-axonal function as well as in diseases such as Multiple Sclerosis, Alzheimer’s Disease, peripheral neuropathies, and after injury, including in developmental disorders, and in the adult. We have also organized sessions to reflect dynamic glial-to-glia interactions and glial–neuronal interactions that influence normal myelin development, disease progression, and repair in the CNS and PNS. Together, the 2022 Myelin GRC “Myelin: Dynamism and Life-Long Plasticity of Myelin Producing Cells in Health and Disease and the GRS “Navigating Myelin Plasticity: A Roadmap through Health and Disease” will: 1) assemble an international meeting of academic scientists, clinician/scientists, and industry scientists engaged in studies of myelination and myelin repair; 2) discuss new and exciting developments in the field by selecting presenters who will largely present unpublished data and by reserving presentation slots for talks selected from the abstracts; 3) promote collaborative interactions to accelerate the pace of discovery to treat diseases of myelin; 4) provide an opportunity for junior attendees of diverse backgrounds to present their work, interact with other scientists, and promote collaborative interactions among all participants.