# Clinical Core

> **NIH NIH U19** · UNIVERSITY OF MARYLAND BALTIMORE · 2024 · $205,555

## Abstract

Project Summary
The specific objective of the Clinical Core is to provide human specimens for the studies outlined in Research
Projects (RP) 1-3. These human specimens will supplement the existing extensive collection of unique banked
specimens that are future-use consented and which will be available for use in RP1-3. These specimens include
specimens from unique immunization and/or challenge studies conducted at Maryland, against S. Typhi, Non-
Typhoidal Salmonella, and Shigella species. Of particular note, as specified in RFA-AI-22-069, support is
requested to obtain additional human specimens only from clinical studies involving subjects who are receiving
licensed vaccines. Blood and duodenal and/or terminal ileum biopsies, from subjects undergoing medically
indicated endoscopy who consent to receive the Ty21a oral typhoid vaccine, will be collected under Protocol
CVD 38000. Blood will also be collected from un-vaccinated controls (Blood Donor CVD 4000) and Ty21a
vaccinated individuals (Blood Donor CVD 5000). The Clinical Core will provide the infrastructure to collect these
unique human clinical specimens, which will supplement the already extensive existing specimen bank. The
leadership of the clinical core are composed of two experienced physician-scientists who also provide patient
care within the University of Maryland Medical Center (UMMC) or as part of the Faculty Practice Office of the
University of Maryland School of Medicine (UMSOM). The clinical core is also staffed by experienced nurse s
that have been trained in GCP and are well acquainted with the research protocols to be utilized for our studies.
The resources being made available through the clinical core and the patient volumes (clinical activity) of the
involved clinics should ensure that sufficient human specimens will be provided for the in-depth immunological
studies proposed in this CCHI application.

## Key facts

- **NIH application ID:** 10823666
- **Project number:** 1U19AI181108-01
- **Recipient organization:** UNIVERSITY OF MARYLAND BALTIMORE
- **Principal Investigator:** Wilbur H. Chen
- **Activity code:** U19 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $205,555
- **Award type:** 1
- **Project period:** 2024-08-20 → 2029-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10823666

## Citation

> US National Institutes of Health, RePORTER application 10823666, Clinical Core (1U19AI181108-01). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10823666. Licensed CC0.

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