# Translational Pathology Core Laboratory Shared Resource (TPCL)

> **NIH NIH P30** · UNIVERSITY OF CALIFORNIA LOS ANGELES · 2024 · $274,513

## Abstract

TRANSLATIONAL PATHOLOGY CORE LABORATORY SHARED RESOURCE (TPCL) 
ABSTRACT 
The Translational Pathology Core Laboratory (TPCL), a UCLA Jonsson Comprehensive Cancer Center (JCCC) 
Shared Resource since 1998, provides pathology services critical for basic, translational, clinical, and population 
cancer research. TPCL provides a College of American Pathologists accredited human tissue biobank, histology 
(animal/human; frozen/formalin-fixed paraffin embedded), laser capture microdissection, immunohistochemistry 
and in-situ hybridization services (established/new antibody optimization), and pathology consultation services. 
TPCL connects cancer researchers with subspecialty pathologists and was an early adopter of digital pathology, 
assisting with custom digital image analysis algorithms for complex evaluations of tissue sections. 
TPCL provided essential services and materials for numerous, recent high-impact studies, including work 
demonstrating that a sodium-glucose transporter is a potential diagnostic and therapeutic target in early-stage 
lung adenocarcinoma, and that therapy-induced tumor secretomes promote resistance and tumor progression. 
TPCL supports many clinical trials, including a recent UCLA-led investigator-initiated clinical trial of dual-cell 
immunotherapy, combining a NY-ESO-1 specific T cell receptor adoptively transferred with NY-ESO-1 peptide- 
pulsed dendritic cell vaccination, with or without ipilimumab-induced CTLA-4 blockade. 
During 2013 – 2018, TPCL developed four-color multiplexed immunofluorescence (MIF) staining for the 
Leica/Aperio slide scanner, which is a unique scanner capability, introduced nine-color MIF with a Perkin-Elmer 
Polaris system, created processes to identify and retrieve remnant biofluids with customized clinical variables, 
initiated a video universal electronic consent for biobanking, built research blood draw order capabilities within 
routine clinical lab orders, collaborated on a UC Virtual Biobank, and added biofluid acquisition, processing and 
storage. TPCL fees are similar to or lower than those of other cancer centers within Los Angeles County. During 
the prior project period, 153 JCCC members from all six Research Programs used TPCL representing 69% of 
overall usage. Their usage resulted in 334 publications, 49% of which were in high-impact (IF ≥10, or field 
leading) journals. TPCL is centrally located to most JCCC labs and occupies ~6,400 sf. 
TPCL Director Sarah Dry, MD (ZY), and Co-Directors Samuel French, MD, PhD (ZY) and Dawn Ward, MD, are 
board-certified, practicing pathologists who conduct basic, translational, and clinical research. Since 2013, Dry 
co-led the UCLA biobanking consent effort, with 39,700 consents in 24 months, using a novel video e-consent 
process. Dry also initiated efforts leading to current TPCL collaborations with UC Davis on a University of 
California (UC) Virtual Biobank. 
Exciting future TPCL directions to support and benefit JCCC research include: (...

## Key facts

- **NIH application ID:** 10824415
- **Project number:** 5P30CA016042-48
- **Recipient organization:** UNIVERSITY OF CALIFORNIA LOS ANGELES
- **Principal Investigator:** SAMUEL FRENCH
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $274,513
- **Award type:** 5
- **Project period:** 1996-12-01 → 2025-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10824415

## Citation

> US National Institutes of Health, RePORTER application 10824415, Translational Pathology Core Laboratory Shared Resource (TPCL) (5P30CA016042-48). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10824415. Licensed CC0.

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