PROJECT SUMMARY – Administrative Core (Core A) The goals of the Administrative Core, located at the Northwestern University Feinberg School of Medicine, are to provide coordination and integration of all Projects and Cores across Northwestern, National Jewish and University of Calgary, as well as dissemination of resources, primary data, and scientific results with the other Cooperative Centers on Human Immunology and to the public. The Administrative Core will accomplish these objectives as outlined in four specific aims: 1) To support communication between Project Investigators, Core Leaders, other Cooperative Centers on Human Immunology Sites, and NIAID Program Staff. In addition, Core A will organize quarterly executive committee hybrid meetings, host an annual in-person scientific meeting of our multidisciplinary investigators, and will host an annual external advisory board review. 2) To provide a structure for the distribution of common resources, and regulatory and budgetary oversight for Project Investigators and Core Leaders. 3) To disseminate the discoveries made by Neu-Lung Consortium Investigators through support of publications and presentations, and to implement sharing of materials, protocols and raw data to other institutions and investigators, including NIAID-directed public databases/repositories. 4) To foster an environment of collaborative interdisciplinary research and mentoring of students, post-doctoral fellows, and investigators. Core A will be led by Dr. Stephanie Eisenbarth, an accomplished immunologist with expertise in both innate and adaptive immunity, and the inaugural director of the new Center for Human Immunobiology (CHI) at Northwestern. Core A will be supported by the expertise of Dr. G. R. Scott Budinger, Chief of Pulmonary and Critical Care Medicine at Northwestern and CHI advisory board member, and an institutionally supported CHI Research Program Coordinator. The primary mission of the CHI is to foster collaboration and provide resources for immunology-focused investigators at Northwestern. As part of that mission, monthly faculty working groups have been formed to identify scientific synergy amongst CHI labs. This proposal is a result of the “Innate Immunity in the Lung” working group, which brings together immunologists with expertise in neutrophil biology, lung pathology, and immune disease modeling. Core A will continue to foster the interactions of this group by hosting monthly hybrid meetings, an annual in-person scientific meeting and oversight of this U19 if awarded. The CHI at Northwestern will provide important resources for this proposal if funded as the breadth of human immunology grows on campus and new initiatives to support trainees focused on human immunology are implemented.