# Core B - Clinical Core

> **NIH NIH U19** · WASHINGTON UNIVERSITY · 2024 · $455,453

## Abstract

PROJECT ABSTRACT – CORE B (CLINICAL CORE)
The Washington University Cooperative Center on Human Immunology (WashU-CCHI) Clinical Core (Core B)
combines the resources of two highly successful clinical research units at Washington University, the Infectious
Disease Clinical Research Unit (IDCRU) led by Rachel Presti, MD, PhD, and the Emergency Care Research
Core (ECRC) led by Philip Mudd, MD, PhD, as well as a Statistical Unit led by Charles Goss, PhD. The combined
units provide highly experienced faculty, clinical coordinators, statisticians, laboratory technicians, data and
quality personnel, and pharmacy support with the expertise to conduct the proposed clinical studies of the
WashU-CCHI. The leads of the three units have a history of successful collaboration with both each other and
the investigators leading the proposed CCHI scientific projects. We have designed our research approach in
close collaboration with scientific leads of Projects 1 and 2 to design cutting edge clinical and translational
research projects that are able to obtain and curate samples and clinical information to address many key
questions in the immunology of both infection and vaccination against influenza and SARS-CoV-2. We have
established functional and collaborative relationships with other Departments and Divisions at Washington
University, including Emergency Medicine, Radiology, Hematology/Oncology, and Pulmonology, which have
allowed us to collect unique samples, including lymph node fine needle aspirates (FNA) and core biopsies (CB),
bone marrow aspirates (BMA), bronchoalveolar lavage (BAL) and endobronchial biopsies (EBBx), in addition to
blood, saliva, and nasal swabs collected in the research units. The IDCRU is well positioned to enroll participants
in vaccine studies that include metabolic labeling with deuterium labeled water to determine the temporal origin
and turnover rate of immune cells as well as biospecimen collection including FNA, CB, BMA, BAL and EBBx.
ECRC is well positioned to enroll participants with acute infection and collect BAL, EBBx as well as blood, saliva,
and nasal swabs. Our processing laboratories have developed seamless protocols to perform initial processing
and collaborate closely with research labs for more specialized processing of samples. Design and analysis of
the clinical protocol and research projects will be enabled by expert statisticians in the Statistical Unit.

## Key facts

- **NIH application ID:** 10824576
- **Project number:** 1U19AI181103-01
- **Recipient organization:** WASHINGTON UNIVERSITY
- **Principal Investigator:** Rachel Margaret Presti
- **Activity code:** U19 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $455,453
- **Award type:** 1
- **Project period:** 2024-09-04 → 2029-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10824576

## Citation

> US National Institutes of Health, RePORTER application 10824576, Core B - Clinical Core (1U19AI181103-01). Retrieved via AI Analytics 2026-05-28 from https://api.ai-analytics.org/grant/nih/10824576. Licensed CC0.

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