# CIRCADIAN REGULATION OF HIF2alpha IN ccRCC

> **NIH NIH R01** · SCRIPPS RESEARCH INSTITUTE, THE · 2024 · $462,992

## Abstract

PROJECT SUMMARY (DESCRIPTION)
Clear cell renal cell carcinoma (ccRCC) is frequently driven by increased activity of the hypoxia-inducible
transcription factor HIF2. Circadian rhythms coordinate behavior and physiology with predictable daily
environmental cycles. Chronic disruption of circadian rhythms, such as that experienced during shift work or
travel across time zones, increases the risk of several types of cancer in people. We have established that
the circadian clock components BMAL1, CRY1, and CRY2 regulate the activity of HIF2.
In Aim 1 of this project, we will determine the molecular mechanisms by which BMAL1, BMAL2, CRY1, and
CRY2 influence HIF2-dependent gene expression in ccRCC cells. In Aim 2 of this project, we will
investigate the impact of depletion of CRY1, CRY2, or BMAL1 on the growth of ccRCC cell lines and
xenograft tumors.

## Key facts

- **NIH application ID:** 10825008
- **Project number:** 2R01CA211187-06A1
- **Recipient organization:** SCRIPPS RESEARCH INSTITUTE, THE
- **Principal Investigator:** Katja A Lamia
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $462,992
- **Award type:** 2
- **Project period:** 2017-08-01 → 2029-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10825008

## Citation

> US National Institutes of Health, RePORTER application 10825008, CIRCADIAN REGULATION OF HIF2alpha IN ccRCC (2R01CA211187-06A1). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10825008. Licensed CC0.

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