# Human Immune Monitoring Center (HIMC) Core

> **NIH NIH U19** · STANFORD UNIVERSITY · 2024 · $194,578

## Abstract

PROJECT SUMMARY 
The Human Immune Monitoring Center (HIMC) has been a comprehensive resource for immunological assays 
at Stanford for fifteen years. The HIMC Core will leverage this facility and its robust infrastructure to provide 
biobanking, assays, and data organization services to the CCHI projects. Coordinating with the Clinical Core, 
blood samples will be processed for PBMC, serum, RNA, and DNA, and biobanked according to optimized and 
standardized procedures. Together with the existing inventory of many thousands of specimens from previous 
CCHI and HIPC studies, these samples will be distributed to CCHI projects as needed, using an existing online 
portal to request specific samples, with approval from an oversight committee. State-of-the-art, standardized 
immune assays will also be applied to the CCHI samples, including CyTOF mass cytometry, multiplexed Luminex 
and Olink cytokine analysis, hemagglutinin inhibition, phospho-flow cytometry, and whole blood RNAseq, to 
provide comprehensive immunological data. As required for specific CCHI projects, custom Luminex panels and 
single-cell multi-omics assays (BD Rhapsody, Mission Bio Tapestri, Parse Evercode, and/or Fluent PIPseq) will 
be performed. Finally, the HIMC Core will integrate data from all standard HIMC assays with clinical and 
demographic metadata using the online database, Stanford Data Miner (SDM). Existing scripts will then allow 
formatting of data from SDM into ImmPort templates for samples, persons, and assay results. 
The HIMC Core will create a valuable database of clinical specimens and comprehensive immunological data, 
that will not only serve the needs of the CCHI U19 projects, but many other projects for years to come.

## Key facts

- **NIH application ID:** 10825313
- **Project number:** 2U19AI057229-21
- **Recipient organization:** STANFORD UNIVERSITY
- **Principal Investigator:** Holden T. Maecker
- **Activity code:** U19 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $194,578
- **Award type:** 2
- **Project period:** 2003-09-01 → 2029-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10825313

## Citation

> US National Institutes of Health, RePORTER application 10825313, Human Immune Monitoring Center (HIMC) Core (2U19AI057229-21). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10825313. Licensed CC0.

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