CORE B, CLINICAL CORE SUMMARY The success of the entire program is contingent upon successful accrual of human samples. The purpose of Core B (Clinical Core) is to provide a centralized resource for the accrual of human lymph node (LN), head and neck, nasopharyngeal swab (NP), peripheral blood mononuclear cells (PBMC), and sera and/or plasma samples. This Core will also ensure the quality and uniformity of handling samples received. In addition to recruitment goals, the goal of this Core is to design, establish, and maintain IRB approval while overseeing the quality control of coded clinical information and donor samples. These functions are crucial to provide a strong foundation for the studies described in the three proposed projects. The Core will be based at LJI at the John and Susan Major Center for Clinical Investigation, the CCHI’s home institution. The Clinical Core will work closely with subcontracts (Liverpool, U.K. and UCSD) to enable the acquisition of additional samples for Projects 1 and 3.