ABSTRACT Support is requested for a Keystone Symposia conference entitled Delivery of Nucleic Acid Therapeutics, organized by Drs. Daniel Siegwart and Kathryn Whitehead. The conference will be held in Banff, Alberta, Canada from January 22-25, 2024. This conference will bring together world-renowned experts to explore the complex science, engineering, and application of nucleic acid delivery systems. The recent overwhelming success of mRNA-based SARS-CoV-2 vaccines has refocused attention on the potential of nucleic acids as medicines. Despite steady progress over decades, the broad application of nucleic acid therapies relies on the development of enabling delivery systems. This conference will highlight cutting-edge strategies to transport nucleic acids into target cells and organs without toxicity, address the challenges of delivering nucleic acids systemically and intracellularly and emphasize exciting clinical applications of nucleic acid delivery technologies. This conference will provide a rare opportunity to convene experts from a broad array of disciplines, including engineering, materials science, biology, chemistry, and medicine with a focus on nucleic acid delivery, which will facilitate stimulating conversations that will guide future development of the field. One aspect that makes this conference completely unique is that it will be held jointly with another Keystone Symposia meeting entitled “Precision Genome Engineering.” Through the joint sessions, attendees will hear from leaders in the gene editing field, Drs. Jennifer Doudna and Feng Zhang, and these and other sessions will facilitate more engagement between these aligned communities. Attendees will leave the conference with an expanded network of colleagues, armed with a new appreciation for delivery challenges, solutions, and applications. Ultimately, these experiences will catalyze the development and execution of new ideas that will bring many more nucleic acid therapies to fruition.