# Quality Control of the cilia proteome

> **NIH NIH R01** · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2024 · $384,801

## Abstract

PROJECT SUMMARY
 Primary cilia organize signaling pathways such as vision, olfaction and Hedgehog signaling and dysfunction
of cilia causes a host of symptoms in disease collectively known as ciliopathies. The movements of signaling
receptors into, inside and out of cilium are critical for the correct regulation of these pathways. Past work from
the lab identified two paths for the regulated exit of signaling receptors out of cilia. One route goes back into the
cell and has now been extensively characterized. Another route packages signaling receptors into extracellular
vesicles (EVs) and its mechanisms remain poorly understood.
 The major goal of this proposal is to determine the molecular mechanisms for signaling receptor packaging
into ciliary EVs. A major goal of this proposal is the generate genetically encoded disrupters of ciliary EV
shedding. These tools will enable a rigorously test of the physiological importance of ectocytosis.

## Key facts

- **NIH application ID:** 10827339
- **Project number:** 2R01GM089933-15
- **Recipient organization:** UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- **Principal Investigator:** Maxence V Nachury
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $384,801
- **Award type:** 2
- **Project period:** 2010-04-01 → 2028-01-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10827339

## Citation

> US National Institutes of Health, RePORTER application 10827339, Quality Control of the cilia proteome (2R01GM089933-15). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10827339. Licensed CC0.

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