PROJECT SUMMARY/ABSTRACT Per- and polyfluoroalkyl substances (PFAS) comprise a class of several thousand compounds that present a major public health problem worldwide. The 4th National Conference on Per- and Polyfluoroalkyl Substances – Environmental Justice and Scientific Discovery, will be held in Ann Arbor, MI, a region affected by PFAS drinking water contamination, to continue growing the impact of the conference by facilitating PFAS information sharing and collaborative research and remediation across the country. This meeting uniquely convenes scientists, government officials, environmental justice activists, affected community members, journalists, utility managers, and lawyers to support and better inform the priorities of diverse PFAS sectors. It also cultivates new cross-sector collaborations to help prevent future PFAS contamination and exposure-related health risks, and leverages a diversity of perspectives to more effectively prevent future exposure and protect human health.