PROJECT SUMMARY The objectives of the 2024 Gordon Research Conference (GRC) “Lymphatics” are to present state-of-the-art research on the lymphatic vascular system, to fuel scientific exchange across race and expertise, and to spearhead new ideas and collaborations. The meeting will bring together investigators in all racial backgrounds and from all career stages converging on lymphatics as one common theme. Specific Aims are (1) To present conceptual advances in research of the lymphatic vascular system and its pathologies; (2) To discuss paradigm shifting findings of lymphatics in different organ systems and their contribution to disease; (3) To integrate knowledge from different disciplines; and (4) To nurture underrepresented, low-income, disabled, women scientists and junior investigators. Sessions will cover conceptual advances in development and disease of lymphatic vessels from basic aspects to potential clinical application. The meeting will in particular, highlight recent insights into the diversity and organ-specificity of lymphatic endothelium. Novel molecular regulators for lymphatic vasculature during bone development, Schlemm’s canal in the eye and lacteals in the intestine will be discussed. New factors for regulating lymphangiogenesis and lymphatic integrity will be introduced. Advances in research of lymphatic malformations, lymphedema and other congenital lymphatic diseases will be discussed. Meeting will also present emerging concepts on the role of lymphatics in atherosclerosis, myocardial infarction, and congestive heart failure. Paradigm shifts in the field will be presented, crosstalk between lymphatics and immune system discussed. Advances in understanding how lymphatics contribute to disease, including cardiovascular inflammation, cancer, autoimmune and neurodegenerative diseases will be highlighted. A main goal for this meeting is to serve as a platform to promote diversity, inclusivity and equality. Abundant opportunities for the presentation of research by underrepresented minorities and early career investigators will be provided. Gordon Research Seminar on Lymphatics organized by junior investigators solely provides additional opportunities for junior investigators to present their work and form collaborations. Aside from presentation and poster sessions, a career development session will be held during Gordon Research Seminar. A “Power Hour” to discuss racial and gender biases and burdens placed on URM in science along with a patient session to allow researchers to learn from patients and a special session hosting NIH official to educate us about NIH’s initiatives and efforts to support lymphatic research will be held. The sponsoring organization GRC is dedicated to advancing the frontiers of scientific research. In accordance with its mission, this conference will place an emphasis on the presentation of unpublished data, high quality science and rich discussions in many fields such as cardiovascular disease, cance...