ABSTRACT Support is requested for a Keystone Symposia conference entitled Stem Cells and Regeneration, organized by Drs. Heinrich Jasper and Emmanuelle Passegué. The conference will be held in Santa Fe, New Mexico from January 22–25, 2024. Regenerative medicine relies on a deep mechanistic understanding of tissue stem cell biology and innovative approaches to reprogram cells and tissues. This Keystone Symposia conference brings together leading researchers who study the biology of tissue stem cells and tissue regeneration and who have employed this knowledge to develop therapeutic applications in regenerative medicine. The program of the meeting explores these processes across diverse tissue types, and thus encompasses stem cell populations and regenerative pathways across biological systems, ranging from hematopoietic stem cells to vascular systems to the retina. A particular focus will be on promoting tissue regeneration even in the absence of endogenous stem cells (as in the retina) as well as on rejuvenation approaches based on in vivo partial reprogramming. This conference will run in parallel with our recurring Keystone Symposia meeting on Emerging Cellular Therapies and will feature two joint scientific sessions that explore cellular approaches in regenerative medicine and gene therapy applications. It is anticipated that facilitating interactions beween speakers and attendees of these two programs will foster new and synergistic collaborations as well as catalyze new ventures to develop and exploit regenerative strategies for therapeutic benefit.